The innate immune system and the clearance of apoptotic cells

A Devitt, LJ Marshall - Journal of leukocyte biology, 2011 - academic.oup.com
Removal of unwanted, effete, or damaged cells through apoptosis, an active cell death
culminating in phagocytic removal of cell corpses, is an important process throughout the …

Drosophila cellular immunity: a story of migration and adhesion

MO Fauvarque, MJ Williams - Journal of cell science, 2011 - journals.biologists.com
Research during the past 15 years has led to significant breakthroughs, providing evidence
of a high degree of similarity between insect and mammalian innate immune responses …

Host Cell Lipid Bodies Triggered by Trypanosoma cruzi Infection and Enhanced by the Uptake of Apoptotic Cells Are Associated With Prostaglandin E2 Generation …

H D'Avila, CG Freire-de-Lima, NR Roque… - Journal of Infectious …, 2011 - academic.oup.com
Lipid bodies (lipid droplets) are lipid-rich organelles with functions in cell metabolism and
signaling. Here, we investigate the mechanisms of Trypanosoma cruzi–induced lipid body …

Myeloid cell turnover and clearance

WJ Janssen, DL Bratton, CV Jakubzick… - Myeloid Cells in …, 2017 - Wiley Online Library
Few, if any, individual cells survive throughout the life of the animal, an observation that sets
up the critical concepts of cell life span, turnover, and removal and maintenance of …

The small GTPase RAB-35 defines a third pathway that is required for the recognition and degradation of apoptotic cells

R Haley, Y Wang, Z Zhou - PLoS Genetics, 2018 - journals.plos.org
In metazoans, apoptotic cells are swiftly engulfed by phagocytes and degraded inside
phagosomes. Multiple small GTPases in the Rab family are known to function in phagosome …

Signaling by the Engulfment Receptor Draper: A Screen in Drosophila melanogaster Implicates Cytoskeletal Regulators, Jun N-Terminal Kinase, and Yorkie

JF Fullard, NE Baker - Genetics, 2015 - academic.oup.com
Draper, the Drosophila melanogaster homolog of the Ced-1 protein of Caenorhabditis
elegans, is a cell-surface receptor required for the recognition and engulfment of apoptotic …

Insights into Jumonji C-domain containing protein 6 (JMJD6): A multifactorial role in foot-and-mouth disease virus replication in cells

P Lawrence, E Rieder - Virus Genes, 2017 - Springer
The Jumonji C-domain containing protein 6 (JMJD6) has had a convoluted history, and
recent reports indicating a multifactorial role in foot-and-mouth disease virus (FMDV) …

S5a binds to death receptor-6 to induce THP-1 monocytes to differentiate through the activation of the NF-κB pathway

Z Wang, C Fan, HF Zhou, JS Lu, MJ Sun… - Journal of Cell …, 2014 - journals.biologists.com
Analyses of supernatants from apoptotic cells have helped in the identification of many
signals that modulate the states of cell activation and differentiation. However, the current …

RAB-35 aids apoptotic cell clearance by regulating cell corpse recognition and phagosome maturation

RC Haley, Y Wang, Z Zhou - bioRxiv, 2018 - biorxiv.org
In metazoans, apoptotic cells are swiftly engulfed by phagocytes and degraded inside
phagosomes. Multiple small GTPases in the Rab family are known to function in phagosome …