[HTML][HTML] Mammalian transient receptor potential TRPA1 channels: from structure to disease

K Talavera, JB Startek, J Alvarez-Collazo… - Physiological …, 2020 - journals.physiology.org
The transient receptor potential ankyrin (TRPA) channels are Ca 2+-permeable nonselective
cation channels remarkably conserved through the animal kingdom. Mammals have only …

Transient receptor potential channels in cardiac health and disease

T Hof, S Chaigne, A Récalde, L Salle, F Brette… - Nature Reviews …, 2019 - nature.com
Transient receptor potential (TRP) channels are nonselective cationic channels that are
generally Ca2+ permeable and have a heterogeneous expression in the heart. In the …

TRPV4 deletion protects heart from myocardial infarction-induced adverse remodeling via modulation of cardiac fibroblast differentiation

RK Adapala, AK Kanugula, S Paruchuri… - Basic research in …, 2020 - Springer
Cardiac fibrosis caused by adverse cardiac remodeling following myocardial infarction can
eventually lead to heart failure. Although the role of soluble factors such as TGF-β is well …

Cardamomin protects from diabetes-induced kidney damage through modulating PI3K/AKT and JAK/STAT signaling pathways in rats

C Gao, X Fei, M Wang, Q Chen, N Zhao - International …, 2022 - Elsevier
Background Diabetic nephropathy is one of the common complications of diabetes mellitus,
which seriously affects the life quality and health of patients. In this study, we aimed to …

TRPA1 inhibition ameliorates pressure overload-induced cardiac hypertrophy and fibrosis in mice

Z Wang, Y Xu, M Wang, J Ye, J Liu, H Jiang, D Ye… - …, 2018 - thelancet.com
Background Recent evidence has indicated that the transient receptor potential ankyrin 1
(TRPA1) is expressed in the cardiovascular system and implicated in the development and …

[HTML][HTML] The role of TRPA1 channels in thermosensation

H Zhang, C Wang, K Zhang, PM Kamau, A Luo, L Tian… - Cell Insight, 2022 - Elsevier
Transient receptor potential ankyrin 1 (TRPA1) is a polymodal nonselective cation channel
sensitive to different physical and chemical stimuli. TRPA1 is associated with many …

Ca2+ Signaling in Cardiac Fibroblasts and Fibrosis-Associated Heart Diseases

J Feng, MK Armillei, AS Yu, BT Liang… - Journal of …, 2019 - mdpi.com
Cardiac fibrosis is the excessive deposition of extracellular matrix proteins by cardiac
fibroblasts and myofibroblasts, and is a hallmark feature of most heart diseases, including …

TRPA1 channel contributes to myocardial ischemia-reperfusion injury

DJ Conklin, Y Guo, MA Nystoriak… - American Journal …, 2019 - journals.physiology.org
Myocardial ischemia-reperfusion (I/R) results in the generation of free radicals, accumulation
of lipid peroxidation-derived unsaturated aldehydes, variable angina (pain), and infarction …

The TRPA1 channel in the cardiovascular system: promising features and challenges

Z Wang, D Ye, J Ye, M Wang, J Liu, H Jiang… - Frontiers in …, 2019 - frontiersin.org
The transient receptor potential ankyrin 1 (TRPA1) channel is a calcium-permeable
nonselective cation channel in the plasma membrane that belongs to the transient receptor …

Essential Oils from Monarda fistulosa: Chemical Composition and Activation of Transient Receptor Potential A1 (TRPA1) Channels

M Ghosh, IA Schepetkin, G Özek, T Özek… - Molecules, 2020 - mdpi.com
Little is known about the pharmacological activity of Monarda fistulosa L. essential oils. To
address this issue, we isolated essential oils from the flowers and leaves of M. fistulosa and …