Sex differences may play a critical role in modulating how chronic or heavy alcohol use
impacts the brain to cause the development of alcohol use disorder (AUD). AUD is a …

Between 2005 and 2009, several research groups identified a strikingly dense inhibitory
input to midbrain dopamine neurons arising from a previously uncharted region posterior to …

Aims Compulsive ethanol intake, characterized by persistent consumption despite negative
consequences, is an addictive behavior identified by the DSM-5 as a central criterion in …

Inhibition can be defined as a phenomenon in which an agent prevents or suppresses a
behavioral state that would otherwise occur. Associative learning studies have extensively …

Background One of the DSM‐5 criteria for Alcohol Use Disorder is continued alcohol
consumption despite negative consequences. This has been modeled in mice using …

Hyperalgesia, which often occurs in people suffering from alcohol use disorder, may drive
excessive drinking and relapse. Emerging evidence suggests that the lateral habenula …

Rationale Preclinical studies report attenuated ethanol-induced conditioned taste aversion
(CTA) following chronic ethanol exposure, suggesting that tolerance develops to the …

Compulsive drug intake is characterized by the continuation of use regardless of negative
consequences. This is modeled preclinically using procedures where a negative stimulus is …

There is strong evidence that ethanol entails aversive effects that can act as a deterrent to
overconsumption. We have found that in doses that support the development of a …

Nicotine, the addictive component of tobacco, has bivalent rewarding and aversive
properties. Recently, the lateral habenula (LHb), a structure that controls ventral tegmental …