Abstract The Mitogen Activated Protein Kinase (MAPK) signaling plays a critical role in the
outcome and the sensitivity to anticancer therapies. Activated MAPK can transmit …

Mitogen-activated protein kinases (MAPKs) mediate a wide variety of cellular behaviors in
response to extracellular stimuli. One of the main subgroups, the p38 MAP kinases, has …

Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) family
members function in a cell context-specific and cell type-specific manner to integrate signals …

Cisplatin, carboplatin and oxaliplatin are platinum-based drugs that are widely used in
cancer chemotherapy. Platinum–DNA adducts, which are formed following uptake of the …

Cancer can be perceived as a disease of communication between and within cells. The
aberrations are pleiotropic, but mitogen-activated protein kinase (MAPK) pathways feature …

Multiple drug resistance (multidrug resistance; MDR), a phenomenon whereby human
tumours that acquire resistance to one type of therapy are found to be resistant to several …

Since the discovery by Rosenberg and collaborators of the antitumor activity of cisplatin 35
years ago, three platinum antitumor drugs (cisplatin, carboplatin and oxaliplatin) have …

The p38 MAPK protein kinases affect a variety of intracellular responses, with well-
recognized roles in inflammation, cell-cycle regulation, cell death, development …

Mitogen-activated protein kinase dual-specificity phosphatase-1 (also called MKP-1,
DUSP1, ERP, CL100, HVH1, PTPN10, and 3CH134) is a member of the threonine-tyrosine …

Five-membered heterocycle derivatives with two aryl groups on adjacent positions include
several classes of natural and unnatural compounds that exhibit a variety of biological and …