Cardiovascular diseases and specifically heart failure (HF) impact global health and impose
a significant economic burden on society. Despite current advances in standard of care, the …

It is widely recognized that inadequate sleep is associated with multiple acute and chronic
diseases and results in increased mortality and morbidity for cardiovascular diseases. In …

Background: Biochemical DNA modification resembles a crucial regulatory layer among
genetic information, environmental factors, and the transcriptome. To identify epigenetic …

Background: DNA methylation acts as a mechanism of gene transcription regulation. It has
recently gained attention as a possible therapeutic target in cardiac hypertrophy and heart …

Impaired myocardial Ca2+ cycling is a critical contributor to the development of heart failure
(HF), causing changes in the contractile function and structure remodeling of the heart …

Rheumatoid arthritis (RA) is an autoimmune chronic inflammatory disease that is still not
well understood in terms of its pathogenesis and presents diagnostic and therapeutic …

Background: Identifying environmentally responsive genetic loci where DNA methylation is
associated with coronary heart disease (CHD) may reveal novel pathways or therapeutic …

Background Heart failure is associated with altered gene expression and DNA methylation.
De novo DNA methylation is associated with gene silencing, but its role in cardiac pathology …

Abstract Background Hepatitis B virus (HBV) infection correlated with the development of
cirrhosis, liver failure and hepatocellular carcinoma (HCC), poses a huge health burden on …

Cardiac fibrosis is defined as excess deposition of extracellular matrix (ECM), resulting in
tissue scarring and organ dysfunction. In recent years, despite the underlying mechanisms …