That certain cell types in the central nervous system are more likely to undergo
neurodegeneration in Parkinson's disease is a widely appreciated but poorly understood …

Impaired protein homeostasis and accumulation of damaged or abnormally modified protein
are common disease mechanisms in many neurodegenerative disorders, including …

Neurodegenerative diseases including Alzheimer (AD) and Parkinson (PD) have attracted
attention in last decades due to their high incidence worldwide. The etiology of these …

Neurons are critically dependent on mitochondrial integrity based on specific morphological,
biochemical, and physiological features. They are characterized by high rates of metabolic …

Mitochondria are highly dynamic organelles which fulfill a plethora of functions. In addition to
their prominent role in energy metabolism, mitochondria are intimately involved in various …

Parkinson's disease (PD) is a chronic progressive neurodegenerative movement disorder
characterized by a profound and selective loss of nigrostriatal dopaminergic neurons …

The quest to disentangle the aetiopathogenesis of Parkinson's disease has been heavily
influenced by the genes associated with the disease. The α-synuclein-centric theory of …

Mutations in parkin are the second most common known cause of Parkinson's disease (PD).
Parkin is an ubiquitin E3 ligase that monoubiquitinates and polyubiquitinates proteins to …

Mutations in parkin lead to early-onset autosomal recessive Parkinson's disease (PD) and
inactivation of parkin is thought to contribute to sporadic PD. Adult knockout of parkin in the …

Although ubiquitin-enriched protein inclusions represent an almost invariant feature of
neurodegenerative diseases, the mechanism underlying their biogenesis remains unclear …