CD8+ T cells can exert both protective and harmful effects on the virus-infected host.
However, there is no systematic method to identify the attributes of a protective CD8+ T cell …

Epitope-based vaccines permit the selection of only a specific subset of epitopes to induce
the necessary immune response, thus providing a rational alternative to conventional design …

HIV/AIDS has become one of the most important infectious diseases with a cumulative
number of almost 60 million infections worldwide. The prevalence and epidemiological …

Antibodies are specialized proteins generated by immune system for high specificity and
affinity binding to target antigens. Because of their essential roles in immune system …

Peptides that bind to and are presented by MHC class I and class II molecules collectively
make up the immunopeptidome. In the context of vaccine development, an understanding of …

Virus proteins alter protein pathways of the host toward the synthesis of viral particles by
breaking and making edges via binding to host proteins. In this study, we developed a …

The cellular arm of the immune response plays a central role in the defense against
intracellular pathogens, such as F. tularensis. To date, whole genome immunoinformatic …

Induction of HIV-1-specific cytotoxic T lymphocyte (CTL) responses largely depends upon
the presentation of CTL epitopes to the CD8+ T cells aided by a large number of different …

The HIV-1 envelope mutates rapidly to evade recognition and killing, and is a major target of
humoral immune responses and vaccine development. Identification of common epitopes for …

Host and viral factors deeply influence the human immunodeficiency virus (HIV) disease
progression. Among them human leukocyte antigen (HLA) locus plays a key role at different …