HLA class I binding of HBZ determines outcome in HTLV-1 infection
A MacNamara, A Rowan, S Hilburn, U Kadolsky… - PLoS …, 2010 - journals.plos.org
CD8+ T cells can exert both protective and harmful effects on the virus-infected host.
However, there is no systematic method to identify the attributes of a protective CD8+ T cell …
However, there is no systematic method to identify the attributes of a protective CD8+ T cell …
In silico predicted mycobacterial epitope elicits in vitro T-cell responses
Epitope-based vaccines permit the selection of only a specific subset of epitopes to induce
the necessary immune response, thus providing a rational alternative to conventional design …
the necessary immune response, thus providing a rational alternative to conventional design …
HIV‐1 evolution in relation to molecular epidemiology and antiretroviral resistance
H Skar, C Hedskog, J Albert - Annals of the New York Academy …, 2011 - Wiley Online Library
HIV/AIDS has become one of the most important infectious diseases with a cumulative
number of almost 60 million infections worldwide. The prevalence and epidemiological …
number of almost 60 million infections worldwide. The prevalence and epidemiological …
Physicochemical determinants of antibody-protein interactions
Antibodies are specialized proteins generated by immune system for high specificity and
affinity binding to target antigens. Because of their essential roles in immune system …
affinity binding to target antigens. Because of their essential roles in immune system …
Predicted MHC peptide binding promiscuity explains MHC class I 'hotspots' of antigen presentation defined by mass spectrometry eluted ligand data
Peptides that bind to and are presented by MHC class I and class II molecules collectively
make up the immunopeptidome. In the context of vaccine development, an understanding of …
make up the immunopeptidome. In the context of vaccine development, an understanding of …
Sequence-and interactome-based prediction of viral protein hotspots targeting host proteins: a case study for HIV Nef
Virus proteins alter protein pathways of the host toward the synthesis of viral particles by
breaking and making edges via binding to host proteins. In this study, we developed a …
breaking and making edges via binding to host proteins. In this study, we developed a …
Whole-Genome Immunoinformatic Analysis of F. tularensis: Predicted CTL Epitopes Clustered in Hotspots Are Prone to Elicit a T-Cell Response
A Zvi, S Rotem, E Bar-Haim, O Cohen, A Shafferman - PloS one, 2011 - journals.plos.org
The cellular arm of the immune response plays a central role in the defense against
intracellular pathogens, such as F. tularensis. To date, whole genome immunoinformatic …
intracellular pathogens, such as F. tularensis. To date, whole genome immunoinformatic …
HLA supertypes contribute in HIV type 1 cytotoxic T lymphocyte epitope clustering in Nef and Gag proteins
Induction of HIV-1-specific cytotoxic T lymphocyte (CTL) responses largely depends upon
the presentation of CTL epitopes to the CD8+ T cells aided by a large number of different …
the presentation of CTL epitopes to the CD8+ T cells aided by a large number of different …
Analysis of HIV-1 envelope evolution suggests antibody-mediated selection of common epitopes among Chinese former plasma donors from a narrow-source …
SM Andrews, Y Zhang, T Dong, SL Rowland-Jones… - Scientific Reports, 2018 - nature.com
The HIV-1 envelope mutates rapidly to evade recognition and killing, and is a major target of
humoral immune responses and vaccine development. Identification of common epitopes for …
humoral immune responses and vaccine development. Identification of common epitopes for …
[HTML][HTML] Key role of human leukocyte antigen in modulating human immunodeficiency virus progression: an overview of the possible applications
A Grifoni, C Montesano, V Colizzi… - World Journal of …, 2015 - ncbi.nlm.nih.gov
Host and viral factors deeply influence the human immunodeficiency virus (HIV) disease
progression. Among them human leukocyte antigen (HLA) locus plays a key role at different …
progression. Among them human leukocyte antigen (HLA) locus plays a key role at different …