Targeting neuraminidase: the next frontier for broadly protective influenza vaccines
NC Wu, AH Ellebedy - Trends in Immunology, 2023 - cell.com
Current seasonal influenza vaccines, which mainly target hemagglutinin (HA), require
annual updates due to the continuous antigenic drift of the influenza virus. Developing an …
annual updates due to the continuous antigenic drift of the influenza virus. Developing an …
Anti-neuraminidase immunity in the combat against influenza
X Zhang, TM Ross - Expert Review of Vaccines, 2024 - Taylor & Francis
Introduction Anti-neuraminidase (NA) immunity correlates with the protection against
influenza virus infection in both human and animal models. The aim of this review is to better …
influenza virus infection in both human and animal models. The aim of this review is to better …
[HTML][HTML] Protective human monoclonal antibodies target conserved sites of vulnerability on the underside of influenza virus neuraminidase
Continuously evolving influenza viruses cause seasonal epidemics and pose global
pandemic threats. Although viral neuraminidase (NA) is an effective drug and vaccine target …
pandemic threats. Although viral neuraminidase (NA) is an effective drug and vaccine target …
[HTML][HTML] Nanoparticle display of neuraminidase elicits enhanced antibody responses and protection against influenza A virus challenge
MN Pascha, M Ballegeer, MC Roelofs, L Meuris… - npj Vaccines, 2024 - nature.com
Current Influenza virus vaccines primarily induce antibody responses against variable
epitopes in hemagglutinin (HA), necessitating frequent updates. However, antibodies …
epitopes in hemagglutinin (HA), necessitating frequent updates. However, antibodies …
[HTML][HTML] Cellular and Molecular Immunity to Influenza Viruses and Vaccines
J Kasten-Jolly, DA Lawrence - Vaccines, 2024 - mdpi.com
Immune responses to influenza (flu) antigens reflect memory of prior infections or
vaccinations, which might influence immunity to new flu antigens. Memory of past antigens …
vaccinations, which might influence immunity to new flu antigens. Memory of past antigens …