Targeting neuraminidase: the next frontier for broadly protective influenza vaccines

NC Wu, AH Ellebedy - Trends in Immunology, 2023 - cell.com
Current seasonal influenza vaccines, which mainly target hemagglutinin (HA), require
annual updates due to the continuous antigenic drift of the influenza virus. Developing an …

Anti-neuraminidase immunity in the combat against influenza

X Zhang, TM Ross - Expert Review of Vaccines, 2024 - Taylor & Francis
Introduction Anti-neuraminidase (NA) immunity correlates with the protection against
influenza virus infection in both human and animal models. The aim of this review is to better …

[HTML][HTML] Protective human monoclonal antibodies target conserved sites of vulnerability on the underside of influenza virus neuraminidase

J Lederhofer, Y Tsybovsky, L Nguyen, JE Raab… - Immunity, 2024 - cell.com
Continuously evolving influenza viruses cause seasonal epidemics and pose global
pandemic threats. Although viral neuraminidase (NA) is an effective drug and vaccine target …

[HTML][HTML] Nanoparticle display of neuraminidase elicits enhanced antibody responses and protection against influenza A virus challenge

MN Pascha, M Ballegeer, MC Roelofs, L Meuris… - npj Vaccines, 2024 - nature.com
Current Influenza virus vaccines primarily induce antibody responses against variable
epitopes in hemagglutinin (HA), necessitating frequent updates. However, antibodies …

[HTML][HTML] Cellular and Molecular Immunity to Influenza Viruses and Vaccines

J Kasten-Jolly, DA Lawrence - Vaccines, 2024 - mdpi.com
Immune responses to influenza (flu) antigens reflect memory of prior infections or
vaccinations, which might influence immunity to new flu antigens. Memory of past antigens …