The Hedgehog (HH) signaling pathway was discovered originally as a key pathway in
embryonic patterning and development. Since its discovery, it has become increasingly …

Hedgehog signalling is fundamental to embryonic development and postnatal tissue
regeneration. Aberrant postnatal Hedgehog signalling leads to several malignancies …

The Smoothened receptor (SMO) mediates signal transduction in the hedgehog pathway,
which is implicated in normal development and carcinogenesis. SMO antagonists can …

Smoothened (SMO), a class Frizzled G protein-coupled receptor (class F GPCR), transduces
the Hedgehog signal across the cell membrane. Sterols can bind to its extracellular cysteine …

Hedgehog (Hh) signaling regulates embryonic development and adult tissue homeostasis
through the GPCR-like protein Smoothened (Smo), but how vertebrate Smo is activated …

Abstract Inhibitors of the Hedgehog (Hh) molecular signaling pathway have emerged in
recent years as a promising new class of potential therapeutics for cancer treatment …

Hedgehog (Hh) signaling is an essential pathway in the human body, and plays a major role
in embryo development and tissue patterning. Constitutive activation of the Hh signaling …

Since its discovery by C. Nüsslein-Volhard and EF Wieschaus, hedgehog (hh) signaling has
come a long way. Today it is regarded as a key regulator in embryogenesis where it governs …

The Smoothened (Smo) receptor is a key transducer of the Hedgehog (Hh) signaling
pathway, which plays a critical role in tissue maintenance and repair. Recent studies have …

The HEDGEHOG-GLI (HH-GLI) signalling is a key pathway critical in embryonic
development, stem cell biology and tissue homeostasis. In recent years, aberrant activation …