Eleven shades of PASEF

ML Mendes, KF Borrmann, G Dittmar - Expert Review of …, 2024 - Taylor & Francis
Introduction The introduction of trapped ion mobility spectrometry (TIMS) in combination with
fast high-resolution time-of-flight (TOF) mass spectrometry to the proteomics field led to a …

[HTML][HTML] Data-independent acquisition: A milestone and prospect in clinical mass spectrometry-based proteomics

K Fröhlich, M Fahrner, E Brombacher… - Molecular & Cellular …, 2024 - Elsevier
Data-independent acquisition (DIA) has revolutionized the field of mass spectrometry (MS)-
based proteomics over the past few years. DIA stands out for its ability to systematically …

Four-Dimensional Data-Independent Acquisition-Based Proteomic Profiling Combined with Transcriptomic Analysis Reveals the Involvement of the Slym1-SlFHY3 …

P Wang, Z Li, L Zhu, F Mo, F Li, R Lv… - Journal of Agricultural …, 2024 - ACS Publications
In green plants, the chloroplast is responsible for light energy transition and organic
assimilation. However, the molecular mechanisms underlying chloroplast development in …

GCMSFormer: A Fully Automatic Method for the Resolution of Overlapping Peaks in Gas Chromatography–Mass Spectrometry

Z Guo, Y Fan, C Yu, H Lu, Z Zhang - Analytical Chemistry, 2024 - ACS Publications
Gas chromatography–mass spectrometry (GC–MS) is one of the most important instruments
for analyzing volatile organic compounds. However, the complexity of real samples and the …

[HTML][HTML] Four-dimensional trapped ion mobility spectrometry proteomics reveals circulating extracellular vesicles encapsulated drivers of nasopharyngeal carcinoma …

P Lu, L Yang, W Chen, K Li, X Chen, S Qu - Talanta, 2025 - Elsevier
Nasopharyngeal carcinoma (NPC) is a head and neck cancer with a high propensity for
early metastatic spread. Emerging evidence shows that extracellular vesicles (EVs) are key …

Differential impact of sex on regulation of skeletal muscle mitochondrial function and protein homeostasis by hypoxia‐inducible factor‐1α in normoxia

N Welch, S Mishra, A Bellar, P Kannan… - The Journal of …, 2024 - Wiley Online Library
Abstract Hypoxia‐inducible factor (HIF)‐1α is continuously synthesized and degraded in
normoxia. During hypoxia, HIF1α stabilization restricts cellular/mitochondrial oxygen …

Liquid-phase separations coupled with ion mobility-mass spectrometry for next-generation biopharmaceutical analysis

DM Makey, BT Ruotolo - Expert Review of Proteomics, 2024 - Taylor & Francis
Introduction The pharmaceutical industry continues to expand its search for innovative
biotherapeutics. The comprehensive characterization of such therapeutics requires many …

Advances in the Clinical Application of High-throughput Proteomics

M Cui, F Deng, ML Disis, C Cheng… - … and hypothesis in …, 2024 - pmc.ncbi.nlm.nih.gov
High-throughput proteomics has become an exciting field and a potential frontier of modern
medicine since the early 2000s. While significant progress has been made in the technical …

Spatial proteomics by trapped ion mobility supported MALDI MS/MS imaging: A first glance into multiplexed and spatial peptide identification

MJ Li, LC Meyer, N Meier, J Witte, M Maldacker… - bioRxiv, 2024 - biorxiv.org
RATIONALE In spatial proteomics, matrix-assisted laser desorption/ionization (MALDI)
imaging enables rapid and cost-effective peptide measurement. Yet, in situ peptide …

Next-Generation Proteomics of Brain Extracellular Vesicles in Schizophrenia Provide New Clues on the Altered Molecular Connectome

C Lorca, M Fernández-Rhodes, JA Sánchez Milán… - Biomedicines, 2024 - mdpi.com
Extracellular vesicles (EVs) are tiny membranous structures that mediate intercellular
communication. The role (s) of these vesicles have been widely investigated in the context of …