A historical overview of peptide chemistry from T. Curtius to E. Fischer to M. Bergmann and
L. Zervas is first presented. Next, the fundamentals of peptide synthesis with a focus on solid …

Cyclic peptides have been attracting a lot of attention in recent decades, especially in the
area of drug discovery, as more and more naturally occurring cyclic peptides with diverse …

Contemporary chemical protein synthesis has been dramatically advanced over the past few
decades, which has enabled chemists to reach the landscape of synthetic …

Conspectus Synthetic proteins are expected to go beyond the boundary of recombinant
DNA expression systems by being flexibly installed with site-specific natural or unnatural …

With the growing popularity of serine/threonine ligation (STL) and cysteine/penicillamine
ligation (CPL) in chemical protein synthesis, facile and general approaches for the …

Peptides can be converted to highly active compounds by introducing appropriate
substituents on the suitable amino acid residue. Although modifiable residues in peptides …

Chemical synthesis of proteins with poor solubility presents a challenging task. The existing
solubilizing tag strategies are not suitable for the expressed protein segment. To address …

The challenging preparation of “difficult peptides” has always hindered the development of
peptide-active pharmaceutical ingredients. Pseudoproline (ψpro) building blocks have been …

Peptide salicylaldehyde esters are the requisite coupling partner in Ser/Thr ligation
reactions towards chemical protein synthesis. In general, it would be cost-effective and …

N‐terminal modifications of proteins have garnered the attention of chemical biologists
because of their critical roles in numerous cellular processes, including protein …