Defining the next generation of severe malaria treatment: a target product profile

J Achan, A Barry, D Leroy, G Kamara, S Duparc… - Malaria Journal, 2024 - Springer
Background Severe malaria is a life-threatening infection, particularly affecting children
under the age of 5 years in Africa. Current treatment with parenteral artemisinin derivatives …

[HTML][HTML] Endothelial transcriptomic analysis identifies biomarkers of severe and cerebral malaria

C Gomes, R Varo, M Duran-Frigola, A Sitoe, R Bila… - JCI insight, 2023 - ncbi.nlm.nih.gov
Malaria can quickly progress from an uncomplicated infection into a life-threatening severe
disease. However, the unspecificity of early symptoms often makes it difficult to identify …

Evasive mechanisms of human VSG and PfEMP1 antigens with link to Vaccine scenario: a review

OA Obi, RN Obiezue, D Eze, DA Adebote - Journal of Parasitic Diseases, 2024 - Springer
Recent fights on the control of trypanosomiasis and malaria focused on underscoring the
concepts of antigen evasive mechanisms with the view to exploit the defensive mechanisms …

Automated malarial retinopathy detection using transfer learning and multi-camera retinal images

AR Kurup, J Wigdahl, J Benson… - biocybernetics and …, 2023 - Elsevier
Cerebral malaria (CM) is a fatal syndrome found commonly in children less than 5 years old
in Sub-saharan Africa and Asia. The retinal signs associated with CM are known as malarial …

Prevalence and factors associated with cerebral malaria among children aged 6 to 59 months with severe malaria in Western Uganda: a hospital-based cross …

B Mseza, PK Kumbowi, M Nduwimana, D Banga… - BMC pediatrics, 2024 - Springer
Introduction Cerebral malaria, caused by Plasmodium falciparum, represents the most
severe neurologic complication of malaria. Its association with high morbidity and mortality …

A Qualitative Method To Assess a History of Cerebral Malaria in Malian Children.

K Traore, A Thera, D Coulibaly, AK Koné… - The American Journal …, 2024 - europepmc.org
The investigation of factors associated with susceptibility to severe malaria is best achieved
using case-control studies. The presence of a history of severe malaria in controls could …

Erythrocyte miRNA-92a-3p interactions with PfEMP1 as determinants of clinical malaria

SR Prabhu, AP Ware, S Umakanth, M Hande… - Functional & Integrative …, 2023 - Springer
Based on the recently added high throughput analysis data on small noncoding RNAs in
modulating disease pathophysiology of malaria, we performed an integrative computational …

Treatment of a patient with severe cerebral malaria during the COVID-19 pandemic in China: A case report

YF Zhu, WJ Xia, W Liu, JM Xie - World Journal of Clinical …, 2024 - pmc.ncbi.nlm.nih.gov
BACKGROUND On June 30, 2021, China received certification from the World Health
Organization for malaria elimination. However, this certification does not signify the absence …

Influência de Variantes Genéticas em CD36, ICAM-1 e HBA na Variabilidade Fenotípica da Drepanocitose e da Malária

ISG Matos - 2024 - search.proquest.com
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical Page 1
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical Influência de …

Analyse du système hôte-parasite chez le patient pour un traitement adapté du neuropaludisme

KB Vianou - 2024 - theses.hal.science
Le neuropaludisme, complication neurologique mortelle du paludisme à Plasmodium
falciparum, survient principalement chez les enfants de moins de cinq ans en Afrique sub …