Evidence implicating Eph receptor tyrosine kinases and their ephrin ligands (that together
make up the 'Eph system') in cancer development and progression has been accumulating …

Eph receptors are the largest family of receptor tyrosine kinases and mediate a myriad of
essential processes in humans from embryonic development to adult tissue homeostasis …

Epigenetic deregulation has emerged as a driver in human malignancies. There is no clear
understanding of the epigenetic alterations in hepatocellular carcinoma (HCC) and of the …

Critical roles for EPH receptor (EPH)–ephrin signalling in a range of chronic and
regenerative diseases are increasingly being recognized. In particular, the complex roles of …

Small cell lung cancer (SCLC) is a subtype of lung cancer with poor prognosis. Expression
array analysis of 23 SCLC cases and 42 normal tissues revealed that EZH2 and other PRC2 …

Insights into cancer genetics can lead to therapeutic opportunities. By cross-referencing
chromosomal changes with an unbiased genetic screen we identify the ephrin receptor A7 …

Simple Summary Protein phosphorylation is a key regulatory mechanism that controls a
wide variety of cellular responses. This process is catalysed by the members of the protein …

The discovery that the Ten-Eleven Translocation (TET) hydroxylases cause DNA
demethylation has fundamentally changed the notion of how DNA methylation is regulated …

The ascending thoracic aorta is designed to withstand biomechanical forces from pulsatile
blood. Thoracic aortic aneurysms and acute aortic dissections (TAADs) occur as a result of …

Numerous studies attest to essential roles for Eph receptors and their ephrin ligands in
controlling cell positioning and tissue patterning during normal and oncogenic development …