Synaptic inhibition plays a crucial role in regulating neuronal excitability, which is the
foundation of nervous system function. This inhibition is largely mediated by the …

The chloride importer NKCC1 and the chloride exporter KCC2 are key regulators of
neuronal chloride concentration. A defective NKCC1/KCC2 expression ratio is associated …

Aim. Neuropathic pain affects 7–10% of the population, with most of the patients receiving
inadequate and incomplete treatment. Owing to the high financial burden and the poor …

Intracellular chloride concentration [Cl–] i is defective in several neurological disorders. In
neurons,[Cl–] i is mainly regulated by the action of the Na+–K+–Cl–importer NKCC1 and the …

Correct operation of neuronal networks depends on the interplay between synaptic
excitation and inhibition processes leading to a dynamic state termed balanced network. In …

Ion disturbances are among the most remarkable deficits in spinal cord injury (SCI). GABA is
an integral part of neural interaction. Action of the GABAA receptor depends on the amount …

Transporters of the solute carrier family 12 (SLC12) carry inorganic cations such as Na+
and/or K+ alongside Cl across the plasma membrane of cells. These tightly coupled …

Chronic pain is a very common problem in patients with spinal cord injury (SCI) as it affects
80% of these patients, which negatively affects their quality of life. Despite many advantages …

The behavioral phenotypes emerge from cognitive architecture comprising attention,
executive functions, and primary communication skills that all have shown remarkable …

One of the main focuses in diagnostic medicine is molecular imaging. Nanoparticles allow
us to image different components of a high-contrast molecule efficiently. In this study, various …