Vitellogenins - Yolk Gene Function and Regulation in Caenorhabditis elegans

MF Perez, B Lehner - Frontiers in physiology, 2019 - frontiersin.org
Vitellogenins are a family of yolk proteins that are by far the most abundant among
oviparous animals. In the model nematode Caenorhabditis elegans, the 6 vitellogenins are …

[HTML][HTML] Non-canonical pattern recognition of a pathogen-derived metabolite by a nuclear hormone receptor identifies virulent bacteria in C. elegans

ND Peterson, YT Samantha, QJ Huang, KA Wani… - Immunity, 2023 - cell.com
Distinguishing infectious pathogens from harmless microorganisms is essential for animal
health. The mechanisms used to identify infectious microbes are not fully understood …

Immunometabolism in Caenorhabditis elegans

SM Anderson, R Pukkila-Worley - PLoS pathogens, 2020 - journals.plos.org
Host metabolism is profoundly altered during bacterial infection, both as a consequence of
immune activation and secondary to virulence strategies of invading pathogens. As a result …

An intestinal sphingolipid confers intergenerational neuroprotection

W Wang, T Sherry, X Cheng, Q Fan, R Cornell… - Nature Cell …, 2023 - nature.com
In animals, maternal diet and environment can influence the health of offspring. Whether and
how maternal dietary choice impacts the nervous system across multiple generations is not …

Opposing action of the FLR-2 glycoprotein hormone and DRL-1/FLR-4 MAP kinases balance p38-mediated growth and lipid homeostasis in C. elegans

SK Torzone, AY Park, PC Breen, NR Cohen… - PLoS …, 2023 - journals.plos.org
Animals integrate developmental and nutritional signals before committing crucial resources
to growth and reproduction; however, the pathways that perceive and respond to these …

Kombucha Tea-associated microbes remodel host metabolic pathways to suppress lipid accumulation

RN DuMez-Kornegay, LS Baker, AJ Morris… - Plos …, 2024 - journals.plos.org
The popularity of the ancient, probiotic-rich beverage Kombucha Tea (KT) has surged in part
due to its purported health benefits, which include protection against metabolic diseases; …

Maintenance of quiescent oocytes by noradrenergic signals

J Kim, M Hyun, M Hibi, YJ You - Nature communications, 2021 - nature.com
All females adopt an evolutionary conserved reproduction strategy; under unfavorable
conditions such as scarcity of food or mates, oocytes remain quiescent. However, the signals …

The molecular tug of war between immunity and fertility: emergence of conserved signaling pathways and regulatory mechanisms

N Naim, FRG Amrit, TB McClendon, JL Yanowitz… - …, 2020 - Wiley Online Library
Reproduction and immunity are energy intensive, intimately linked processes in most
organisms. In women, pregnancy is associated with widespread immunological adaptations …

PQM-1 controls hypoxic survival via regulation of lipid metabolism

T Heimbucher, J Hog, P Gupta, CT Murphy - Nature communications, 2020 - nature.com
Animals have evolved responses to low oxygen conditions to ensure their survival. Here, we
have identified the C. elegans zinc finger transcription factor PQM-1 as a regulator of the …

Endomitosis controls tissue-specific gene expression during development

LM van Rijnberk, R Barrull-Mascaró… - PLoS …, 2022 - journals.plos.org
Polyploid cells contain more than 2 copies of the genome and are found in many plant and
animal tissues. Different types of polyploidy exist, in which the genome is confined to either 1 …