High levels of impulsive behaviours are a clinically significant symptom in a range of
psychiatric disorders, such as attention deficit hyperactivity disorder, bipolar disorder …

Vulnerability to drug abuse is related to both reward seeking and impulsivity, two constructs
thought to have a biological basis in the prefrontal cortex (PFC). This review addresses …

Successful decision making often requires weighing a given option's costs against its
associated benefits, an ability that appears perturbed in virtually every severe mental illness …

Prior work suggests that there may be two distinct pathways of alcohol use disorder (AUD)
risk: one associated with positive emotion enhancement and behavioral impulsivity, and …

Rationale Deficient response inhibition is a prominent feature of many pathological
conditions characterised by impulsive and compulsive behaviour. Clinically effective doses …

Chronic exposure to addictive drugs enhances cAMP response element binding protein
(CREB)-regulated gene expression in nucleus accumbens (NAc), and these effects are …

High impulsivity, mediated through ventral striatal dopamine signalling, represents an
established risk factor for substance abuse, and may likewise confer vulnerability to …

Impulse control and/or gambling disorders can be triggered by dopamine agonist therapies
used to treat Parkinson9s disease, but the cognitive and neurobiological mechanisms …

Maladaptive decision making is associated with several neuropsychiatric disorders,
including problem gambling and suicidal behavior. The prevalence of these disorders is …

Studies in rats, monkeys and humans have established that the medial prefrontal cortex is
crucial for the ability to exert adaptive control over behavior. Here, we review studies on the …