Mechanisms of fungal dissemination
AB Strickland, M Shi - Cellular and Molecular Life Sciences, 2021 - Springer
Fungal infections are an increasing threat to global public health. There are more than six
million fungal species worldwide, but less than 1% are known to infect humans. Most of …
million fungal species worldwide, but less than 1% are known to infect humans. Most of …
Cryptococcal Disease in Diverse Hosts
DB Meya, PR Williamson - New England Journal of Medicine, 2024 - Mass Medical Soc
Key Points Cryptococcal Disease in Diverse Hosts Worldwide, cryptococcal meningitis kills
up to 180,000 persons annually and is the most common cause of nonviral meningitis in the …
up to 180,000 persons annually and is the most common cause of nonviral meningitis in the …
Importance of Clinical Isolates in Cryptococcus neoformans Research
KM Jackson, M Ding, K Nielsen - Journal of Fungi, 2023 - mdpi.com
The human pathogenic fungus Cryptococcus neoformans is a global health concern.
Previous research in the field has focused on studies using reference strains to identify …
Previous research in the field has focused on studies using reference strains to identify …
Divergent neuroimmune signatures in the cerebrospinal fluid predict differential gender-specific survival among patients with HIV-associated cryptococcal meningitis
Introduction Survival among people with HIV-associated cryptococcal meningitis (CM)
remains low, particularly among women, despite the currently optimal use of antifungal …
remains low, particularly among women, despite the currently optimal use of antifungal …
Southern African HIV Clinicians Society guideline for the prevention, diagnosis and management of cryptococcal disease among HIV-infected persons: 2019 update
Background Early diagnosis of HIV infection and early initiation of ART before
immunosuppression is the most important strategy to reduce the incidence of CM and CM …
immunosuppression is the most important strategy to reduce the incidence of CM and CM …
Single nucleotide polymorphisms are associated with strain-specific virulence differences among clinical isolates of Cryptococcus neoformans
KM Jackson, TJY Kono, JJ Betancourt, Y Wang… - Nature …, 2024 - nature.com
Studies across various pathogens highlight the importance of pathogen genetic differences
in disease manifestation. In the human fungal pathogen Cryptococcus neoformans …
in disease manifestation. In the human fungal pathogen Cryptococcus neoformans …
Cryptococcal immune reconstitution inflammatory syndrome: from blood and cerebrospinal fluid biomarkers to treatment approaches
VMS Brienze, JC André, E Liso, I Vlasova-St. Louis - Life, 2021 - mdpi.com
Immune reconstitution inflammatory syndrome (IRIS) presents as an exaggerated immune
reaction that occurs during dysregulated immune restoration in immunocompromised …
reaction that occurs during dysregulated immune restoration in immunocompromised …
Establishment of a novel scoring model for mortality risk prediction in HIV-infected patients with cryptococcal meningitis
T Zhao, XL Xu, JM Nie, XH Chen, ZS Jiang… - BMC infectious …, 2021 - Springer
Background Cryptococcal meningitis (CM) remains a leading cause of death in HIV-infected
patients, despite advances in CM diagnostic and therapeutic strategies. This study was …
patients, despite advances in CM diagnostic and therapeutic strategies. This study was …
Hematologic alterations and early mortality in a cohort of HIV positive African patients
F Ciccacci, F Lucaroni, R Latagliata, L Morciano… - PLoS …, 2020 - journals.plos.org
Introduction Infection with Human Immunodeficiency Virus (HIV) is highly prevalent
worldwide, especially in Sub-Saharan Africa, where anaemia is also widespread. HIV …
worldwide, especially in Sub-Saharan Africa, where anaemia is also widespread. HIV …
Cerebrospinal fluid early fungicidal activity as a surrogate endpoint for cryptococcal meningitis survival in clinical trials
Background In cryptococcal meningitis phase 2 clinical trials, early fungicidal activity (EFA)
of Cryptococcus clearance from cerebrospinal fluid (CSF) is used as a surrogate endpoint …
of Cryptococcus clearance from cerebrospinal fluid (CSF) is used as a surrogate endpoint …