Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics

S Qin, W Xiao, C Zhou, Q Pu, X Deng, L Lan… - Signal transduction and …, 2022 - nature.com
Pseudomonas aeruginosa (P. aeruginosa) is a Gram-negative opportunistic pathogen that
infects patients with cystic fibrosis, burn wounds, immunodeficiency, chronic obstructive …

Targeting the holy triangle of quorum sensing, biofilm formation, and antibiotic resistance in pathogenic bacteria

RV Sionov, D Steinberg - Microorganisms, 2022 - mdpi.com
Chronic and recurrent bacterial infections are frequently associated with the formation of
biofilms on biotic or abiotic materials that are composed of mono-or multi-species cultures of …

C/EBPβ-dependent epigenetic memory induces trained immunity in hematopoietic stem cells

B de Laval, J Maurizio, PK Kandalla, G Brisou… - Cell stem cell, 2020 - cell.com
Hematopoietic stem cells (HSCs) maintain life-long production of immune cells and can
directly respond to infection, but sustained effects on the immune response remain unclear …

Antimicrobial resistance and virulence: a successful or deleterious association in the bacterial world?

A Beceiro, M Tomás, G Bou - Clinical microbiology reviews, 2013 - Am Soc Microbiol
Hosts and bacteria have coevolved over millions of years, during which pathogenic bacteria
have modified their virulence mechanisms to adapt to host defense systems. Although the …

Roles of Two-Component Systems in Pseudomonas aeruginosa Virulence

M Sultan, R Arya, KK Kim - International journal of molecular sciences, 2021 - mdpi.com
Pseudomonas aeruginosa is an opportunistic pathogen that synthesizes and secretes a
wide range of virulence factors. P. aeruginosa poses a potential threat to human health …

Pseudomonas biofilm matrix composition and niche biology

EE Mann, DJ Wozniak - FEMS microbiology reviews, 2012 - academic.oup.com
Biofilms are a predominant form of growth for bacteria in the environment and in the clinic.
Critical for biofilm development are adherence, proliferation, and dispersion phases. Each of …

Biofilm Matrix and Its Regulation in Pseudomonas aeruginosa

Q Wei, LZ Ma - International journal of molecular sciences, 2013 - mdpi.com
Biofilms are communities of microorganisms embedded in extracellular polymeric
substances (EPS) matrix. Bacteria in biofilms demonstrate distinct features from their free …

Two-component systems required for virulence in Pseudomonas aeruginosa

VI Francis, EC Stevenson, SL Porter - FEMS microbiology letters, 2017 - academic.oup.com
Pseudomonas aeruginosa is a versatile opportunistic pathogen capable of infecting a broad
range of hosts, in addition to thriving in a broad range of environmental conditions outside of …

The Pseudomonas aeruginosa opportunistic pathogen and human infections

S De Bentzmann, P Plésiat - Environmental microbiology, 2011 - Wiley Online Library
Pseudomonas aeruginosa, a Gram‐negative environmental species and an opportunistic
microorganism, establishes itself in vulnerable patients, such as those with cystic fibrosis or …

Roles of two-component regulatory systems in antibiotic resistance

ARP Tierney, PN Rather - Future microbiology, 2019 - Taylor & Francis
Two-component regulatory systems (TCSs) are a major mechanism by which bacteria sense
and respond to changes in their environment. TCSs typically consist of two proteins that …