Isoniazid (INH) is an antituberculosis drug associated with idiosyncratic liver injury in
susceptible patients. INH‐induced hepatotoxicity remains a significant clinical problem, but …

Besides physicochemical properties, careful design of biomolecular surface corona can
dictate therapeutic potential of nanoparticles. Therefore, we demonstrate a new approach to …

Decades of nanomedicine research has demonstrated the importance of physicochemical
properties to tightly regulate cytotoxicity of nanoparticles. Wherein, the tailor-made surface …

The prolonged use of isoniazid (INH)–a highly effective drug in the treatment of tuberculosis–
causes fatal liver injury. In order to overcome this adverse effect, a unique amide codrug was …

Morphological and metabolic aberrations in the liver caused by long-term use of anti-
tubercular agent isoniazid (INH) have been an issue of great concern in tuberculosis …

AIM To overcome the hazardous effects on liver caused by long-term use of antitubercular
agent isoniazid (INH) by developing a novel hepatoprotective prodrug strategy by …

ABSTRACT INTRODUCTION: β-lapachone (β-LAP), a potent antitumor agent, has limited
therapeutic use due to its low solubility and high toxicity. A possible strategy to overcome …

The long-course treatment of tuberculosis with isoniazid (INH) leads to hazardous side
effects on liver and poor patient compliance. To overcome these toxic effects caused by INH …

This study was performed to investigate the effects of curcumin supplementation on
intestinal barrier function, serum biochemical index, amino acid profile, and mRNA …

One of the most common adverse effects, in the case of medicines used voluntarily or not, of
over dosage, or even of drugs administered in therapeutic doses, is hepatic injury, which is …