Illuminating the druggable genome: Pathways to progress
KR Sharma, CM Colvis, GP Rodgers, DM Sheeley - Drug discovery today, 2023 - Elsevier
There are∼ 4500 genes within the 'druggable genome', the subset of the human genome
that expresses proteins able to bind drug-like molecules, yet existing drugs only target a few …
that expresses proteins able to bind drug-like molecules, yet existing drugs only target a few …
Metal–Organic Frameworks for Nerve Repair and Neural Stem Cell Therapy
L Meng, N Ren, M Dong, S Zhang… - Advanced Functional …, 2024 - Wiley Online Library
Recently, neurological disorders have led to a growing global burden of fatalities and
disabilities. The limited capacity for natural self‐regeneration poses a significant challenge …
disabilities. The limited capacity for natural self‐regeneration poses a significant challenge …
Nucleic acid and protein methylation modification in renal diseases
J Jin, X Liu, W Shao, X Meng - Acta Pharmacologica Sinica, 2024 - nature.com
Although great efforts have been made to elucidate the pathological mechanisms of renal
diseases and potential prevention and treatment targets that would allow us to retard kidney …
diseases and potential prevention and treatment targets that would allow us to retard kidney …
Genome-wide CRISPR screen identifies phospholipid scramblase 3 as the biological target of mitoprotective drug SS-31
Background: The synthetic tetra-peptide SS-31 shows promise in alleviating mitochondrial
dysfunction associated with common diseases. However, the precise pharmacological basis …
dysfunction associated with common diseases. However, the precise pharmacological basis …
[HTML][HTML] Inhibition of retinoic acid signaling in proximal tubular epithelial cells protects against acute kidney injury
M Yang, LN Lopez, M Brewer, R Delgado, A Menshikh… - JCI insight, 2023 - ncbi.nlm.nih.gov
Retinoic acid receptor (RAR) signaling is essential for mammalian kidney development but,
in the adult kidney, is restricted to occasional collecting duct epithelial cells. We now show …
in the adult kidney, is restricted to occasional collecting duct epithelial cells. We now show …
Tryptophan Metabolites Target Transmembrane and Immunoglobulin Domain-Containing 1 Signaling to Augment Renal Tubular Injury
M Belghasem, W Yin, S Lotfollahzadeh, X Yang… - The American Journal of …, 2023 - Elsevier
Chronic kidney disease (CKD) is characterized by the accumulation of uremic toxins and
renal tubular damage. Tryptophan-derived uremic toxins [indoxyl sulfate (IS) and kynurenine …
renal tubular damage. Tryptophan-derived uremic toxins [indoxyl sulfate (IS) and kynurenine …
[HTML][HTML] Traditional Chinese Medicine and renal regeneration: experimental evidence and future perspectives
D Zhang, H Jiang, X Yang, S Zheng, Y Li, S Liu, X Xu - Chinese Medicine, 2024 - Springer
Repair of acute kidney injury (AKI) is a typical example of renal regeneration. AKI is
characterized by tubular cell death, peritubular capillary (PTC) thinning, and immune system …
characterized by tubular cell death, peritubular capillary (PTC) thinning, and immune system …
Inhibition of Retinoic Acid Signaling in Proximal Tubular Epithelial cells Protects against Acute Kidney Injury by Enhancing Kim-1-dependent Efferocytosis
M Yang, LN Lopez, M Brewer, R Delgado, A Menshikh… - bioRxiv, 2023 - biorxiv.org
Retinoic acid receptor (RAR) signaling is essential for mammalian kidney development, but
in the adult kidney is restricted to occasional collecting duct epithelial cells. We now show …
in the adult kidney is restricted to occasional collecting duct epithelial cells. We now show …