Resistance to immune checkpoint inhibitors (ICIs) is a major issue of the current era in
cancer immunotherapy. Immune evasion is a multi-factorial event, which occurs generally at …

Gastrointestinal (GI) cancers are highly heterogeneous at multiple levels. Tumor
heterogeneity can be captured by molecular profiling, such as genetic, epigenetic …

DNA mismatch repair (MMR) corrects mismatched DNA bases arising from multiple sources
including polymerase errors and base damage. By detecting spontaneous mutagenesis …

Methods accurately predicting the responses of colorectal cancer (CRC) and colorectal
cancer liver metastasis (CRLM) to personalized chemotherapy remain limited due to tumor …

Colorectal cancer is caused by a sequence of somatic genomic alterations affecting driver
genes in core cancer pathways. Here, to understand the functional and prognostic impact of …

This study aims to identify colorectal cancer (CRC)-related proteomic profiles and develop a
prediction model for CRC onset by integrating proteomic profiles with genetic and non …

Colorectal cancer (CRC) remains a challenging and deadly disease with high tumor
microenvironment (TME) heterogeneity. Using an integrative multi-omics analysis and …

Background As a common malignant tumor, esophageal carcinoma (ESCA) has a low early
diagnosis rate and poor prognosis. This study aimed to construct the prognostic features …

Rationale: Mitochondrial dysfunction caused by mitochondrial DNA (mtDNA) mutations and
subsequent metabolic defects are closely involved in tumorigenesis and progression in a …

The clinical implications of extrachromosomal DNA (ecDNA) in cancer therapy remain
largely elusive. Here, we present a comprehensive analysis of ecDNA amplification spectra …