[HTML][HTML] Molecular, subcellular, and arrhythmogenic mechanisms in genetic RyR2 disease
ED Fowler, S Zissimopoulos - Biomolecules, 2022 - mdpi.com
The ryanodine receptor (RyR2) has a critical role in controlling Ca2+ release from the
sarcoplasmic reticulum (SR) throughout the cardiac cycle. RyR2 protein has multiple …
sarcoplasmic reticulum (SR) throughout the cardiac cycle. RyR2 protein has multiple …
Timing mechanisms to control heart rhythm and initiate arrhythmias: roles for intracellular organelles, signalling pathways and subsarcolemmal Ca2+
DA Terrar - … Transactions of the Royal Society B, 2023 - royalsocietypublishing.org
Rhythms of electrical activity in all regions of the heart can be influenced by a variety of
intracellular membrane bound organelles. This is true both for normal pacemaker activity …
intracellular membrane bound organelles. This is true both for normal pacemaker activity …
[HTML][HTML] Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders
MC Miotto, S Reiken, A Wronska, Q Yuan… - Nature …, 2024 - nature.com
Heart failure, the leading cause of mortality and morbidity in the developed world, is
characterized by cardiac ryanodine receptor 2 channels that are hyperphosphorylated …
characterized by cardiac ryanodine receptor 2 channels that are hyperphosphorylated …
Arrhythmogenic mechanism of a novel ryanodine receptor mutation underlying sudden cardiac death
Y Qian, D Zuo, J Xiong, Y Yin, R Qi, X Ma, A Yan… - Europace, 2023 - academic.oup.com
Abstract Aims The ryanodine receptor 2 (RyR2) is essential for cardiac muscle excitation–
contraction coupling; dysfunctional RyR2 participates in the development of inherited …
contraction coupling; dysfunctional RyR2 participates in the development of inherited …
Natriuretic Peptide Receptor B Protects Against Atrial Fibrillation by Controlling Atrial cAMP Via Phosphodiesterase 2
BACKGROUND: β-AR (β-adrenergic receptor) stimulation regulates atrial electrophysiology
and Ca2+ homeostasis via cAMP-dependent mechanisms; however, enhanced β-AR …
and Ca2+ homeostasis via cAMP-dependent mechanisms; however, enhanced β-AR …
[HTML][HTML] Exercise and calcium in the heart
OJ Kemi - Current Opinion in Physiology, 2023 - Elsevier
Highlights•Ca 2+ links excitation to contraction and drives cardiac pump function.•Exercise
adaptation enhances pump function via alteration to cellular Ca 2+ handling.•Cardiomyocyte …
adaptation enhances pump function via alteration to cellular Ca 2+ handling.•Cardiomyocyte …
[PDF][PDF] Molecular, Subcellular, and Arrhythmogenic Mechanisms in Genetic RyR2 Disease. Biomolecules 2022, 12, 1030
ED Fowler, S Zissimopoulos - Molecular Pathogenesis of Cardiac …, 2022 - mdpi.com
The ryanodine receptor (RyR2) has a critical role in controlling Ca2+ release from the
sarcoplasmic reticulum (SR) throughout the cardiac cycle. RyR2 protein has multiple …
sarcoplasmic reticulum (SR) throughout the cardiac cycle. RyR2 protein has multiple …