Cholesterol homeostasis is vital for proper cellular and systemic functions. Disturbed
cholesterol balance underlies not only cardiovascular disease but also an increasing …

Cellular lipid metabolism and homeostasis are controlled by sterol regulatory-element
binding proteins (SREBPs). In addition to performing canonical functions in the …

Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) remain
without effective therapies. The mechanistic target of rapamycin complex 1 (mTORC1) …

Non-alcoholic fatty liver disease (NAFLD) is a growing cause of chronic liver disease
worldwide. It is characterised by steatosis, liver inflammation, hepatocellular injury and …

Fatty acid and fat synthesis in the liver is a highly regulated metabolic pathway that is
important for very low-density lipoprotein (VLDL) production and thus energy distribution to …

Sterol regulatory element-binding proteins (SREBPs) are a family of membrane-bound
transcription factors that activate genes encoding enzymes required for synthesis of …

Sterol Regulatory Element Binding Protein-1c is a transcription factor that controls the
synthesis of lipids from glucose in the liver, a process which is of utmost importance for the …

Through unknown mechanisms, insulin activates the sterol regulatory element-binding
protein (SREBP1c) transcription factor to promote hepatic lipogenesis. We find that this …

Steatosis is an accumulation of triglycerides in the liver. Although an excessive availability of
plasma fatty acids is an important determinant of steatosis, lipid synthesis from glucose …

Yttrium‐90 transarterial radioembolization (TARE) is a locoregional therapy (LRT) for
hepatocellular carcinoma (HCC). In this study, we present overall survival (OS) outcomes in …