Oxidative damage in neurodegeneration: roles in the pathogenesis and progression of Alzheimer disease
M Perluigi, F Di Domenico… - Physiological …, 2024 - journals.physiology.org
Alzheimer disease (AD) is associated with multiple etiologies and pathological mechanisms,
among which oxidative stress (OS) appears as a major determinant. Intriguingly, OS arises …
among which oxidative stress (OS) appears as a major determinant. Intriguingly, OS arises …
[HTML][HTML] Mitochondrial dysfunction, oxidative stress, and neuroinflammation: Intertwined roads to neurodegeneration
Oxidative stress develops as a response to injury and reflects a breach in the cell's
antioxidant capacity. Therefore, the fine-tuning of reactive oxygen species (ROS) generation …
antioxidant capacity. Therefore, the fine-tuning of reactive oxygen species (ROS) generation …
Effects of aneuploidy on cell behaviour and function
Aneuploidy, a genomic alternation characterized by deviations in the copy number of
chromosomes, affects organisms from early development through to aging. Although it is a …
chromosomes, affects organisms from early development through to aging. Although it is a …
Primary mitochondrial disease and secondary mitochondrial dysfunction: importance of distinction for diagnosis and treatment
DM Niyazov, SG Kahler, RE Frye - Molecular syndromology, 2016 - karger.com
Mitochondrial disease refers to a heterogeneous group of disorders resulting in defective
cellular energy production due to abnormal oxidative phosphorylation (oxphos). Primary …
cellular energy production due to abnormal oxidative phosphorylation (oxphos). Primary …
Resveratrol and brain mitochondria: a review
FR Jardim, FT de Rossi, MX Nascimento… - Molecular …, 2018 - Springer
Abstract Resveratrol (3, 4', 5-trihydroxystilbene; C 14 H 12 O 3) is a polyphenolic phytoalexin
found in grapes, berries, peanuts, and wines. Resveratrol has been viewed as an …
found in grapes, berries, peanuts, and wines. Resveratrol has been viewed as an …
[HTML][HTML] Gut microbiota, an additional hallmark of human aging and neurodegeneration
Gut microbiota represents a diverse and dynamic population of microorganisms harbouring
the gastrointestinal tract, which influences host health and disease. Bacterial colonization of …
the gastrointestinal tract, which influences host health and disease. Bacterial colonization of …
Mitochondrial DNA methylation as a next-generation biomarker and diagnostic tool
V Iacobazzi, A Castegna, V Infantino… - Molecular genetics and …, 2013 - Elsevier
Recent expansion of our knowledge on epigenetic changes strongly suggests that not only
nuclear DNA (nDNA), but also mitochondrial DNA (mtDNA) may be subjected to epigenetic …
nuclear DNA (nDNA), but also mitochondrial DNA (mtDNA) may be subjected to epigenetic …
Neurological phenotypes for Down syndrome across the life span
IT Lott - Progress in brain research, 2012 - Elsevier
This chapter reviews the neurological phenotype of Down syndrome (DS) in early
development, childhood, and aging. Neuroanatomic abnormalities in DS are manifested as …
development, childhood, and aging. Neuroanatomic abnormalities in DS are manifested as …
Mitochondrial dysfunction as a central actor in intellectual disability-related diseases: an overview of Down syndrome, autism, Fragile X and Rett syndrome
Clinical manifestations typical of mitochondrial diseases are often present in various genetic
syndromes associated with intellectual disability, a condition leading to deficit in cognitive …
syndromes associated with intellectual disability, a condition leading to deficit in cognitive …
[HTML][HTML] An overview about oxidation in clinical practice of skin aging
SAM Silva, B Michniak-Kohn… - Anais brasileiros de …, 2017 - SciELO Brasil
Free radicals are unstable chemical species, highly reactive, being formed by cellular
entities of different tissues. Increased production of these species without proper effective …
entities of different tissues. Increased production of these species without proper effective …