Mitochondria are a main source of cellular energy. Oxidative phosphorylation (OXPHOS) is
the major process of aerobic respiration. Enzyme complexes of the electron transport chain …

Nonalcoholic fatty liver disease (NAFLD) has emerged as the most common chronic liver
disease worldwide and is strongly associated with the presence of oxidative stress …

This review examines the generation of reactive oxygen species by mammalian
mitochondria, and the status of different sites of production in redox signaling and pathology …

Short-and medium-chain fatty acids (SCFAs and MCFAs), independently of their cellular
signaling functions, are important substrates of the energy metabolism and anabolic …

Mitochondrial production of superoxide and hydrogen peroxide is potentially important in
cell signaling and disease. Eleven distinct mitochondrial sites that differ markedly in capacity …

Lipids are a fundamental class of organic molecules implicated in a wide range of biological
processes related to their structural diversity, and based on this can be broadly classified …

It is well established that muscle contractions during exercise lead to elevated levels of
reactive oxygen species (ROS) in skeletal muscle. These highly reactive molecules have …

Antioxidant supplements are commonly consumed by endurance athletes to minimize
exercise-induced oxidative stress, with the intention of enhancing recovery and improving …

Mitochondrial radical production is important in redox signaling, aging and disease, but the
relative contributions of different production sites are poorly understood. We analyzed the …

The sites and rates of mitochondrial production of superoxide and H 2 O 2 in vivo are not yet
defined. At least 10 different mitochondrial sites can generate these species. Each site has a …