The tumor suppressor p53 functions primarily as a transcription factor. Mutation of the TP53
gene alters its response pathway, and is central to the development of many cancers. The …

Testicular cancer is the most common malignancy among men between 14 and 44 years of
age, and its incidence has risen over the past two decades in Western countries. Both …

Most complex trait-associated variants are located in non-coding regulatory regions of the
genome, where they have been shown to disrupt transcription factor (TF)-DNA binding …

Our understanding of cancer is being transformed by exploring clonal diversity, drug
resistance, and causation within an evolutionary framework. The therapeutic resilience of …

We present genome-wide data from 40 individuals dating to c. 16,900 to 550 years ago in
northeast Asia. We describe hitherto unknown gene flow and admixture events in the region …

Decades of research have shown that mutations in the p53 stress response pathway affect
the incidence of diverse cancers more than mutations in other pathways. However, most …

Genome editing of human induced pluripotent stem cells (iPSCs) is instrumental for
functional genomics, disease modeling, and regenerative medicine. However, low editing …

Genome-wide association studies (GWAS) have transformed understanding of susceptibility
to testicular germ cell tumors (TGCTs), but much of the heritability remains unexplained …

The p53 transcription factor confers its potent tumor suppressor functions primarily through
the regulation of a large network of target genes. The recent explosion of next generation …

The p53 protein is structurally and functionally divided into five domains. The proline-rich
domain is localized at amino acids 55–100. 319 missense mutations were identified solely …