Haematological malignancies were previously thought to be driven solely by genetic or
epigenetic lesions within haematopoietic cells. However, the niches that maintain and …

Inflammation, especially chronic inflammation, plays a pivotal role in tumorigenesis and
metastasis through various mechanisms and is now recognized as a hallmark of cancer and …

Cancer stem cells (CSCs) are tumor cells that have the principal properties of self-renewal,
clonal tumor initiation capacity, and clonal long-term repopulation potential. CSCs reside in …

Little is known about how leukemia cells alter the bone marrow (BM) niche to facilitate their
own growth and evade chemotherapy. Here, we provide evidence that acute myeloid …

Introduction VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome
is a recently described, late-onset, acquired autoinflammatory disorder caused by mutations …

Therapy-related myeloid neoplasms (t-MN) arise as a late effect of chemotherapy and/or
radiation administered for a primary condition, typically a malignant disease, solid organ …

Clonally restricted hematopoiesis is a common aging-associated biological state that
predisposes to subsequent development of a hematological malignancy or cardiovascular …

In this study, we present integrated quantitative proteome, transcriptome, and methylome
analyses of hematopoietic stem cells (HSCs) and four multipotent progenitor (MPP) …

Hematopoietic stem cells (HSCs) rely on instructive cues from the bone marrow (BM) niche
to maintain their quiescence and adapt blood production to the organism's needs …

The bone marrow microenvironment is composed of heterogeneous cell populations of non-
hematopoietic cells with complex phenotypes and undefined trajectories of maturation …