Cyclic peptides in pipeline: what future for these great molecules?

L Costa, E Sousa, C Fernandes - Pharmaceuticals, 2023 - mdpi.com
Cyclic peptides are molecules that are already used as drugs in therapies approved for
various pharmacological activities, for example, as antibiotics, antifungals, anticancer, and …

Structural diversity and biological activities of cyclic depsipeptides from fungi

X Wang, X Gong, P Li, D Lai, L Zhou - Molecules, 2018 - mdpi.com
Cyclic depsipeptides (CDPs) are cyclopeptides in which amide groups are replaced by
corresponding lactone bonds due to the presence of a hydroxylated carboxylic acid in the …

Peptides, peptidomimetics, and polypeptides from marine sources: a wealth of natural sources for pharmaceutical applications

R Sable, P Parajuli, S Jois - Marine drugs, 2017 - mdpi.com
Nature provides a variety of peptides that are expressed in most living species. Evolutionary
pressure and natural selection have created and optimized these peptides to bind to …

Marine bioactive peptides—an overview of generation, structure and application with a focus on food sources

M Pavlicevic, E Maestri, M Marmiroli - Marine Drugs, 2020 - mdpi.com
The biggest obstacles in the application of marine peptides are two-fold, as in the case of
non-marine plant and animal-derived bioactive peptides: elucidating correlation between …

Marine organisms as a prolific source of bioactive depsipeptides

M Zeng, J Tao, S Xu, X Bai, H Zhang - Marine Drugs, 2023 - mdpi.com
Depsipeptides, an important group of polypeptides containing residues of hydroxy acids and
amino acids linked together by amide and ester bonds, have potential applications in …

Therapeutic Potential of Marine-Derived Cyclic Peptides as Antiparasitic Agents

R Ribeiro, L Costa, E Pinto, E Sousa, C Fernandes - Marine Drugs, 2023 - mdpi.com
Parasitic diseases still compromise human health. Some of the currently available
therapeutic drugs have limitations considering their adverse effects, questionable efficacy …

Anti-herpes simplex virus activities and mechanisms of marine derived compounds

C Hao, Z Xu, C Xu, R Yao - Frontiers in Cellular and Infection …, 2024 - frontiersin.org
Herpes simplex virus (HSV) is the most widely prevalent herpes virus worldwide, and the
herpetic encephalitis and genital herpes caused by HSV infection have caused serious …

The structure–activity relationship of marine peptides: A review

TJ Ashaolu, BP Pham, Z Molnár… - International Journal of …, 2024 - Wiley Online Library
Oceans cover over 70% of the Earth's surface and provide home to structurally diverse
marine organisms. These creatures contribute to more than half of the biodiversity of the …

Absolute Stereochemistry Determination of bioactive marine-derived cyclopeptides by liquid chromatography methods: An update review (2018–2022)

C Fernandes, R Ribeiro, M Pinto, A Kijjoa - Molecules, 2023 - mdpi.com
Cyclopeptides are considered as one of the most important classes of compounds derived
from marine sources, due to their structural diversity and a myriad of their biological and …

Marine Depsipeptide Nobilamide I Inhibits Cancer Cell Motility and Tumorigenicity via Suppressing Epithelial–Mesenchymal Transition and MMP2/9 Expression

TC Le, S Pulat, J Lee, GJ Kim, H Kim, EY Lee… - ACS …, 2022 - ACS Publications
A cyclic depsipeptide, nobilamide I (1), along with the known peptide A-3302-B/TL-119 (2),
was isolated from the saline cultivation of the marine-derived bacterium …