Biological importance of arginine: A comprehensive review of the roles in structure, disorder, and functionality of peptides and proteins

MN Gupta, VN Uversky - International Journal of Biological Macromolecules, 2023 - Elsevier
Abstract Arginine shows Jekyll and Hyde behavior in several respects. It participates in
protein folding via ionic and H-bonds and cation-pi interactions; the charge and …

On the regulation of human D‐aspartate oxidase

V Rabattoni, Z Motta, M Miceli, G Molla… - Protein …, 2023 - Wiley Online Library
The human flavoenzyme D‐aspartate oxidase (hDASPO) controls the level of D‐aspartate in
the brain, a molecule acting as an agonist of NMDA receptors and modulator of AMPA and …

Development of a biocatalytic cascade for synthesis of 2-oxo-4-(hydroxymethylphosphinyl) butyric acid in one pot

J Xu, K Zhang, H Cao, H Li, F Cheng… - Biocatalysis and …, 2021 - Taylor & Francis
Oxo-4-(hydroxymethylphosphinyl) butyric acid (PPO) is an important precursor compound
for the broad-spectrum herbicide l-glufosinate (L-PPT). In this study, the gene of d-amino …

[HTML][HTML] Mechanistic insights into the loss-of-function mechanisms of rare human D-amino acid oxidase variants implicated in amyotrophic lateral sclerosis

AK Padhi, KYJ Zhang - Scientific Reports, 2020 - nature.com
Impaired enzymatic activity in D-amino acid oxidase (DAAO) caused by missense mutations
has been shown to trigger amyotrophic lateral sclerosis (ALS) through an abnormal …

Biological Importance of Arginine: Roles in Structure, Disorder, and Functionality of Peptides and Proteins

MN Gupta, VN Uversky - 2023 - preprints.org
Abstract Arginine shows Jekyll and Hyde behavior in several respects. It participates in
protein folding via ionic and H-bonds and cation-pi interactions; the charge and …

[HTML][HTML] Yin and Yang in Post-Translational Modifications of Human D-Amino Acid Oxidase

S Sacchi, V Rabattoni, M Miceli… - Frontiers in Molecular …, 2021 - frontiersin.org
In the central nervous system, the flavoprotein D-amino acid oxidase is responsible for
catabolizing D-serine, the main endogenous coagonist of N-methyl-D-aspartate receptor …

The pLG72-DAAO Pathway Regulates D-Amino Acids in the Central Nervous System, and Protects Against Neurodegenerative Disorders such as Alzheimer's …

C Baum - jmsgr.tamhsc.edu
Background: Alzheimer's disease (AD) is a multifactorial neurodegenerative disease that
presents in individuals with gradual cognitive decline. 1 Its prevalence has increased 148 …