Recent transcriptomic, histological and functional studies have begun to shine light on the
fibroblasts present in the meninges, choroid plexus and perivascular spaces of the brain and …

Fibrosis is part of a tissue repair response to injury, defined as increased deposition of
extracellular matrix. In some instances, fibrosis is beneficial; however, in the majority of …

Brain vascular calcification is a prevalent age-related condition often accompanying
neurodegenerative and neuroinflammatory diseases. The pathogenesis of large-vessel …

Following lesions to the central nervous system, scar tissue forms at the lesion site. Injury
often severs axons and scar tissue is thought to block axonal regeneration, resulting in …

Pericytes, the mural cells surrounding microcirculation, are gaining increasing attention for
their roles in health and disease of the central nervous system (CNS). As an essential part of …

The blood-brain barrier (BBB) is a complex and dynamic physiological interface between
brain parenchyma and cerebral vasculature. It is composed of closely interacting cells and …

The gelatinases, matrix metalloproteinase 2 (MMP-2) and MMP-9, are key for leukocyte
penetration of the brain parenchymal border in neuroinflammation and the functional …

Although platelet-derived growth factor receptor beta (PDGFR-β) mediates the recruitment of
vascular pericytes into ischemic lesion to restore the blood-brain barrier (BBB) dysfunction …

Pericytes play an indispensable role in various organs and biological processes, such as
promoting angiogenesis, regulating microvascular blood flow, and participating in immune …

Central nervous system diseases involving the parenchymal microvessels are frequently
associated with a 'microvasculopathy', which includes different levels of neurovascular unit …