Objective We investigated the comparative efficacy and tolerability of pharmacological
treatment strategies for the treatment of acute bipolar depression. Data sources A systematic …

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Objective: The role of antidepressants in the acute treatment of bipolar depression remains a
contentious issue. A previous meta-analysis of randomized controlled trials (RCTs) …

Objective This study examined the risk of antidepressant-induced manic switch in patients
with bipolar disorder treated either with antidepressant monotherapy or with an …

The 2002 American Psychiatric Association (APA) guidelines for the treatment of bipolar
disorder recommended more conservative use of antidepressants. This change in …

Tondo L, Vázquez G, Baldessarini RJ. Mania associated with antidepressant treatment:
comprehensive meta‐analytic review. Objective: To review available data pertaining to risk …

Objective: The prevalence, characteristics, and possible risk factors associated with
antidepressant‐induced mania remain poorly described. The present review sought to …

Objectives To clarify the clinical features preceding the onset of bipolar disorder (BD) has
become a public health priority for the prevention of high morbidity and mortality. BD …

Objective: The singular phenomenon of switching from depression to its opposite state of
mania or hypomania, and vice versa, distinguishes bipolar disorder from all other psychiatric …

OBJECTIVE: While guidelines for treating patients with bipolar depression recommend
discontinuing antidepressants within 6 months after remission, few studies have assessed …