Complement-mediated activation of the adaptive immune responses: role of C3d in linking the innate and adaptive immunity
FR Toapanta, TM Ross - Immunologic research, 2006 - Springer
C3d is the final degradation product of the third component of complement (C3). When
conjugated to an antigen, C3d enhances immune responses to the fused antigen. Therefore …
conjugated to an antigen, C3d enhances immune responses to the fused antigen. Therefore …
Influenza virus-like particles elicit broader immune responses than whole virion inactivated influenza virus or recombinant hemagglutinin
RA Bright, DM Carter, S Daniluk, FR Toapanta… - Vaccine, 2007 - Elsevier
Influenza virus is a highly infectious respiratory pathogen that results in severe morbidity and
mortality. The current licensed trivalent vaccine formulations in the US are made from virus …
mortality. The current licensed trivalent vaccine formulations in the US are made from virus …
Complement amplification revisited
HU Lutz, E Jelezarova - Molecular immunology, 2006 - Elsevier
Complement amplification in blood takes place not only on activating surfaces, but in plasma
as well, where it is maintained primarily by C3b2–IgG complexes. Regular products of C3 …
as well, where it is maintained primarily by C3b2–IgG complexes. Regular products of C3 …
Cross-clade protective immune responses to influenza viruses with H5N1 HA and NA elicited by an influenza virus-like particle
RA Bright, DM Carter, CJ Crevar, FR Toapanta… - PloS one, 2008 - journals.plos.org
Background Vaccination is a cost-effective counter-measure to the threat of seasonal or
pandemic outbreaks of influenza. To address the need for improved influenza vaccines and …
pandemic outbreaks of influenza. To address the need for improved influenza vaccines and …
A DNA vaccine targeting the receptor-binding domain of Clostridium difficile toxin A
DF Gardiner, T Rosenberg, J Zaharatos, D Franco… - Vaccine, 2009 - Elsevier
Clostridium difficile is a pathogen with increasing severity for which host antibody responses
provide protection from disease. DNA vaccination has several advantages compared to …
provide protection from disease. DNA vaccination has several advantages compared to …
Elicitation of protective immune responses using a bivalent H5N1 VLP vaccine
CJ Crevar, TM Ross - Virology journal, 2008 - Springer
Background Currently licensed human vaccines are subtype-specific and do not protect
against pandemic H5N1 viruses. Previously, our group has reported on the construction of …
against pandemic H5N1 viruses. Previously, our group has reported on the construction of …
C3d and the septal microvasculature as a predictor of chronic lung allograft dysfunction
CM Magro, AE Abbas, K Seilstad, AL Pope-Harman… - Human immunology, 2006 - Elsevier
Studies have shown a potential role for humoral rejection in the evolution of lung graft
dysfunction, apparently based on antibodies without human leukocyte antigen specificity …
dysfunction, apparently based on antibodies without human leukocyte antigen specificity …
B cell targeting by molecular adjuvants for enhanced immunogenicity
T Sicard, A Kassardjian, JP Julien - Expert Review of Vaccines, 2020 - Taylor & Francis
Introduction Adjuvants are critical components of vaccines to improve the quality and
durability of immune responses. Molecular adjuvants are a specific subclass of adjuvants …
durability of immune responses. Molecular adjuvants are a specific subclass of adjuvants …
Enhancement of anti-DIII antibodies by the C3d derivative P28 results in lower viral titers and augments protection in mice
Abstract Antibodies generated against West Nile virus (WNV) during infection are essential
for controlling dissemination. Recent studies have demonstrated that epitopes in all three …
for controlling dissemination. Recent studies have demonstrated that epitopes in all three …
C3d enhances immune responses using low doses of DNA expressing the HIV-1 envelope from codon-optimized gene sequences
JF Bower, KL Sanders, TM Ross - Current HIV research, 2005 - ingentaconnect.com
DNA vaccinations effectively induce both humoral and cellular immune responses to
immunogens from diverse infectious agents. However, DNA vaccines expressing the HIV-1 …
immunogens from diverse infectious agents. However, DNA vaccines expressing the HIV-1 …