Structural variation in the 3D genome
Structural and quantitative chromosomal rearrangements, collectively referred to as
structural variation (SV), contribute to a large extent to the genetic diversity of the human …
structural variation (SV), contribute to a large extent to the genetic diversity of the human …
Two major mechanisms of chromosome organization
The spatial organization of chromosomes has long been connected to their polymeric nature
and is believed to be important for their biological functions, including the control of …
and is believed to be important for their biological functions, including the control of …
Enhancer–promoter contact formation requires RNAPII and antagonizes loop extrusion
Homotypic chromatin interactions and loop extrusion are thought to be the two main drivers
of mammalian chromosome folding. Here we tested the role of RNA polymerase II (RNAPII) …
of mammalian chromosome folding. Here we tested the role of RNA polymerase II (RNAPII) …
Promoter-proximal CTCF binding promotes distal enhancer-dependent gene activation
N Kubo, H Ishii, X Xiong, S Bianco… - Nature structural & …, 2021 - nature.com
The CCCTC-binding factor (CTCF) works together with the cohesin complex to drive the
formation of chromatin loops and topologically associating domains, but its role in gene …
formation of chromatin loops and topologically associating domains, but its role in gene …
Targeted degradation of CTCF decouples local insulation of chromosome domains from genomic compartmentalization
The molecular mechanisms underlying folding of mammalian chromosomes remain poorly
understood. The transcription factor CTCF is a candidate regulator of chromosomal …
understood. The transcription factor CTCF is a candidate regulator of chromosomal …
Complex multi-enhancer contacts captured by genome architecture mapping
The organization of the genome in the nucleus and the interactions of genes with their
regulatory elements are key features of transcriptional control and their disruption can cause …
regulatory elements are key features of transcriptional control and their disruption can cause …
RNA-mediated symmetry breaking enables singular olfactory receptor choice
Olfactory receptor (OR) choice provides an extreme example of allelic competition for
transcriptional dominance, where every olfactory neuron stably transcribes one of …
transcriptional dominance, where every olfactory neuron stably transcribes one of …
[HTML][HTML] Cell-type specialization is encoded by specific chromatin topologies
W Winick-Ng, A Kukalev, I Harabula, L Zea-Redondo… - Nature, 2021 - nature.com
Abstract The three-dimensional (3D) structure of chromatin is intrinsically associated with
gene regulation and cell function,–. Methods based on chromatin conformation capture have …
gene regulation and cell function,–. Methods based on chromatin conformation capture have …
Single-allele chromatin interactions identify regulatory hubs in dynamic compartmentalized domains
The promoters of mammalian genes are commonly regulated by multiple distal enhancers,
which physically interact within discrete chromatin domains. How such domains form and …
which physically interact within discrete chromatin domains. How such domains form and …
Loop-extrusion and polymer phase-separation can co-exist at the single-molecule level to shape chromatin folding
Loop-extrusion and phase-separation have been proposed as mechanisms that shape
chromosome spatial organization. It is unclear, however, how they perform relative to each …
chromosome spatial organization. It is unclear, however, how they perform relative to each …