Under physiological conditions, adenosine triphosphate (ATP) is present at low levels in the
extracellular milieu, being massively released by stressed or dying cells. Once outside the …

The P2X7 receptor is a cation channel activated by high concentrations of adenosine
triphosphate (ATP). Upon long-term activation, it complexes with membrane proteins forming …

The P2X7 receptor is a trimeric ATP-gated cation channel found predominantly, but not
exclusively, on immune cells. P2X7 activation results in a number of downstream events …

P2X7 is a transmembrane receptor expressed in multiple cell types including neurons,
dendritic cells, macrophages, monocytes, B and T cells where it can drive a wide range of …

Glioblastoma (GBM) is the most lethal brain tumor in adults. Radiation, together with
temozolomide is the standard treatment, but nevertheless, relapse occurs in nearly all cases …

Glioblastoma (GBM) is the most common and malignant form of primary brain tumor with a
median survival time of 14–16 months in GBM patients. Surgical treatment with …

P2X7 receptor is an ATP-gated cation channel that upon agonist interaction leads to cellular
influx of Na+ and Ca 2+ and efflux of K+. P2X7 is expressed by a wide variety of cells and its …

Cancer is still one of the world's most pressing health-care challenges, leading to a high
number of deaths worldwide. Immunotherapy is a new developing therapy that boosts …

The P2X7 receptor (P2X7R) is an ATP-gated membrane ion channel that is expressed by
multiple cell types. Following activation by extracellular ATP, the P2X7R mediates a broad …

Abstract The P2X receptor 7 (P2X7R) is a plasma membrane receptor sensing extracellular
ATP associated with a wide variety of cellular functions. It is most commonly expressed on …