Background Randomised trials (also referred to as 'randomised controlled trials' or 'trials')
are the optimal way to minimise bias in evaluating the effects of competing treatments …

BACKGROUND Importance of Recruitment and Attrition The goal of a research study is to
gain a clear understanding of a population from a study test sample. That generalizability …

By understanding common motivations for participating in observational research studies,
clinicians may better understand the perceived benefits of research participation from their …

In this paper, we distinguish decisions about cooperation with medical research from
decisions about research participation. We offer an empirical and theoretical exploration of …

In spite of a growing literature on pharmaceuticalization, little is known about the
pharmaceutical industry's investments in research and development (R&D). Information …

Background Low participation rates can lead to sampling bias, delays in completion and
increased costs. Strategies to improve participation rates should address reasons for non …

Background Clinical research exposes patient participants to unproved methods and
research procedures in order to gather generalizable knowledge to benefit others. While …

Background Organoid technology enables the cultivation of human tissues in a dish. Its
precision medicine potential could revolutionize the Cystic Fibrosis (CF) field. We provide a …

All trials use protocols to standardize practice within and between trial centres and to enable
replication of an experiment across space and time. However, while 'centre effects' have …

Background There is substantial need to rigorously evaluate existing and new therapies for
pulmonary arterial hypertension (PAH) and other severe and relatively rare conditions …