The development of metastatic cancer is a multistage process, which often requires decades
to complete. Impairments in DNA damage control and DNA repair in cancer cell precursors …

DNA methylation is an essential epigenetic mark crucial for normal mammalian
development. This modification controls the expression of a unique class of genes …

Background Despite a multifactorial approach being taken for the evaluation of bull semen
quality in many animal breeding centres worldwide, reliable prediction of bull fertility is still a …

The process of aging refers to physiological changes that occur to an organism as time
progresses and involves changes to DNA, proteins, metabolism, cells, and organs. Like the …

• During the differentiation of male germ cells into spermatozoa, there are several windows
of epigenome sensitivity to environmental factors.• The epigenome of bull sperm exhibits …

Genomic imprinting refers to the mono-allelic and parent-specific expression of a subset of
genes. While long recognized for their role in embryonic development, imprinted genes …

In humans and model species, alterations of sperm DNA methylation patterns have been
reported in cases of spermatogenesis defects, male infertility and exposure to toxins or …

Multiple lines of evidence suggest that paternal psychological stress contributes to an
increased prevalence of neuropsychiatric and metabolic diseases in the progeny. While …

Spermatogenesis relies on exquisite stem cell homeostasis, the carefully balanced self-
renewal and differentiation of spermatogonial stem cells (SSCs). Disturbing this equilibrium …

Most studies on mechanisms by which prenatal stress affects offspring behavior were
conducted during late pregnancy using in vivo models; studies on the effect of …