Oncogenic mutations of PIK3CA in human cancers
The involvement of the PIK3CA gene product p110α, the catalytic subunit of
phosphatidylinositol 3-kinase (PI3K), in human cancer has been suggested for over 15 …
phosphatidylinositol 3-kinase (PI3K), in human cancer has been suggested for over 15 …
PI3K as a target for therapy in haematological malignancies
A Khwaja - Phosphoinositide 3-kinase in Health and Disease …, 2011 - Springer
Although classical mutations in genes such as PIK3CA and PTEN occur at a relatively low
frequency in haematological malignancies, activation of PI3K signalling is often detected in …
frequency in haematological malignancies, activation of PI3K signalling is often detected in …
Isoform-selective phosphoinositide 3′-kinase inhibitors inhibit CXCR4 signaling and overcome stromal cell–mediated drug resistance in chronic lymphocytic …
M Niedermeier, BT Hennessy, ZA Knight… - Blood, The Journal …, 2009 - ashpublications.org
Phosphoinositide 3-kinases (PI3Ks) are among the most frequently activated signaling
pathways in cancer. In chronic lymphocytic leukemia (CLL), signals from the …
pathways in cancer. In chronic lymphocytic leukemia (CLL), signals from the …
Autocrine insulin-like growth factor-I signaling promotes growth and survival of human acute myeloid leukemia cells via the phosphoinositide 3-kinase/Akt pathway
KT Doepfner, O Spertini, A Arcaro - Leukemia, 2007 - nature.com
Insulin-like growth factor (IGF) signaling plays an important role in various human cancers.
Therefore, the role of insulin-like growth factor I (IGF-I) signaling in growth and survival of …
Therefore, the role of insulin-like growth factor I (IGF-I) signaling in growth and survival of …
Differential effects of selective inhibitors targeting the PI3K/AKT/mTOR pathway in acute lymphoblastic leukemia
S Badura, T Tesanovic, H Pfeifer, S Wystub… - PloS one, 2013 - journals.plos.org
Purpose Aberrant PI3K/AKT/mTOR signaling has been linked to oncogenesis and therapy
resistance in various malignancies including leukemias. In Philadelphia chromosome (Ph) …
resistance in various malignancies including leukemias. In Philadelphia chromosome (Ph) …
Mutations of the PIK3CA gene in diffuse large B cell lymphoma
Y Baohua, Z Xiaoyan, Z Tiecheng, Q Tao… - Diagnostic Molecular …, 2008 - journals.lww.com
Abstract The PI3K/AKT pathway might be involved in the development of some certain
diffuse large B-cell lymphoma (DLBCL) by as-yet unclear mechanisms. PIK3CA mutations in …
diffuse large B-cell lymphoma (DLBCL) by as-yet unclear mechanisms. PIK3CA mutations in …
Mutations in the catalytic subunit of class IA PI3K confer leukemogenic potential to hematopoietic cells
S Horn, U Bergholz, M Jücker, JA McCubrey… - Oncogene, 2008 - nature.com
Constitutive activation of the phosphoinositide 3-kinase (PI3K)–AKT pathway is observed in
up to 70% of acute myelogenous leukemia. To investigate the relevance of an intrinsic PI3K …
up to 70% of acute myelogenous leukemia. To investigate the relevance of an intrinsic PI3K …
PIK3CA amplification is predictive of poor prognosis in Tunisian patients with nasopharyngeal carcinoma
A Fendri, A Khabir, W Mnejja… - Cancer …, 2009 - Wiley Online Library
PI3Ks (phosphatidylinositol 3‐kinases) are lipid kinases that regulate signalling pathways
involved in cell proliferation, motility, and adhesion. Somatic mutations and amplification of …
involved in cell proliferation, motility, and adhesion. Somatic mutations and amplification of …
[HTML][HTML] Coexpression of hyperactivated AKT1 with additional genes activated in leukemia drives hematopoietic progenitor cells to cell cycle block and apoptosis
Y Tang, C Halvarsson, A Nordigården, K Kumar… - Experimental …, 2015 - Elsevier
The phosphatidylinositol 3-kinase/AKT pathway is an integral component of signaling
involved in the development of many cancers, including myeloid leukemias such as chronic …
involved in the development of many cancers, including myeloid leukemias such as chronic …
[HTML][HTML] Selective small molecule inhibitors of p110α and δ isoforms of phosphoinosityl-3-kinase are cytotoxic to human acute myeloid leukemia progenitors
Y Xing, B Gerhard, DE Hogge - Experimental Hematology, 2012 - Elsevier
The phosphoinosityl-3-kinase (PI3K) pathway is frequently constitutively active in blast cells
from acute myeloid leukemia (AML) patients. RNA and protein from all four catalytic isoforms …
from acute myeloid leukemia (AML) patients. RNA and protein from all four catalytic isoforms …