LTP and LTD, the long-term potentiation and depression of excitatory synaptic transmission,
are widespread phenomena expressed at possibly every excitatory synapse in the …

Hebb postulated that, to store information in the brain, assemblies of excitatory neurons
coding for a percept are bound together via associative long-term synaptic plasticity. In this …

Coronary artery disease is prevalent in different causes of out-of-hospital cardiac arrest
(OHCA), especially in individuals presenting with shockable rhythms of ventricular …

At a synapse, fast synchronous neurotransmitter release requires localization of Ca 2+
channels to presynaptic active zones. How Ca 2+ channels are recruited to active zones …

The physical distance between presynaptic Ca2+ channels and the Ca2+ sensors that
trigger exocytosis of neurotransmitter-containing vesicles is a key determinant of the …

Although opioids are highly effective for the treatment of pain, they are also known to be
intensely addictive. There has been a massive research investment in the development of …

The dentate gyrus provides the main input to the hippocampus. Information reaches the CA3
region through mossy fibre synapses made by dentate granule cell axons. Synaptic plasticity …

Spatio-temporal configurations of distributed activity in the brain is thought to contribute to
the coding of neuronal information and synaptic contacts between nerve cells could play a …

Sialic acids are a family of nine-carbon acidic monosaccharides that occur naturally at the
end of sugar chains attached to the surfaces of cells and soluble proteins. In the human …

Voltage-gated ion channels have to be at the right place in the right number to endow
individual neurons with their specific character. Their biophysical properties together with …