The merger of photoredox catalysis with transition metal catalysis, termed
metallaphotoredox catalysis, has become a mainstay in synthetic methodology over the past …

Transition-metal-catalyzed C–H activation has developed a contemporary approach to the
omnipresent area of retrosynthetic disconnection. Scientific researchers have been tempted …

The development of late-stage functionalization (LSF) methodologies, particularly C–H
functionalization, has revolutionized the field of organic synthesis. Over the past decade …

Synthetic organic electrosynthesis has grown in the past few decades by achieving many
valuable transformations for synthetic chemists. Although electrocatalysis has been popular …

In the pursuit of new pharmaceuticals and agrochemicals, chemists in the life science
industry require access to mild and robust synthetic methodologies to systematically modify …

Recent research in medicinal chemistry has suggested that there is a correlation between
an increase in the fraction of sp 3 carbons—those bonded to four other atoms—in drug …

Reaction generality is crucial in determining the overall impact and usefulness of synthetic
methods. Typical generalization protocols require a priori mechanistic understanding and …

Conspectus Recently, alkene dicarbofunctionalization, ie, the powerful organic synthesis
method of alkene difunctionalization with two carbon sources, emerged as a formidable …

An electrochemically driven nickel-catalyzed enantioselective reductive cross-coupling of
aryl aziridines with alkenyl bromides has been developed, affording enantioenriched β-aryl …

Cross-coupling platforms are traditionally built around a sequence of closed-shell steps,
such as oxidative addition, transmetalation, and reductive elimination. Herein, we describe a …