Idiosyncratic drug reactions are a significant cause of morbidity and mortality for patients;
they also markedly increase the uncertainty of drug development. The major targets are skin …

The normal metabolism of drugs can generate metabolites that have intrinsic chemical
reactivity towards cellular molecules, and therefore have the potential to alter biological …

The development and progression of hepatocellular carcinoma (HCC) are dependent on its
local microenvironment. Hypoxia and inflammation are two critical factors that shape the …

Drug-induced liver injury (DILI) is a challenging clinical event in medicine, particularly
because of its ability to present with a variety of phenotypes including that of autoimmune …

Responses to drugs and pharmacological treatments differ considerably between
individuals. Importantly, only 50%–75% of patients have been shown to react adequately to …

Drug-induced liver injury (DILI) is a leading cause of attrition during the early and late stages
of drug development and after a drug is marketed. DILI is generally classified as either …

Neutrophil infiltration is a hallmark of alcoholic steatohepatitis; however, the underlying
mechanisms remain unclear. We previously reported that chronic-plus-binge ethanol …

Current management of anesthesia‐associated complications falls short in terms of both
efficacy and safety. Nanomaterials with versatile properties and unique nano‐bio …

Adverse drug reactions (ADRs) remain a major complication of drug therapy and can be
classified as 'on-target'or 'off-target'(idiosyncratic) reactions. On-target reactions can be …

Drug-induced liver injury (DILI) is a major safety concern in drug development and clinical
drug therapy. However, the underlying mechanism of DILI is little known. It is difficult to …