Idiosyncratic adverse drug reactions: current concepts
J Uetrecht, DJ Naisbitt - Pharmacological reviews, 2013 - ASPET
Idiosyncratic drug reactions are a significant cause of morbidity and mortality for patients;
they also markedly increase the uncertainty of drug development. The major targets are skin …
they also markedly increase the uncertainty of drug development. The major targets are skin …
Managing the challenge of chemically reactive metabolites in drug development
BK Park, A Boobis, S Clarke, CEP Goldring… - Nature Reviews Drug …, 2011 - nature.com
The normal metabolism of drugs can generate metabolites that have intrinsic chemical
reactivity towards cellular molecules, and therefore have the potential to alter biological …
reactivity towards cellular molecules, and therefore have the potential to alter biological …
[PDF][PDF] Hypoxia‐inducible factor‐1α/interleukin‐1β signaling enhances hepatoma epithelial–mesenchymal transition through macrophages in a hypoxic‐inflammatory …
J Zhang, Q Zhang, Y Lou, Q Fu, Q Chen, T Wei… - …, 2018 - Wiley Online Library
The development and progression of hepatocellular carcinoma (HCC) are dependent on its
local microenvironment. Hypoxia and inflammation are two critical factors that shape the …
local microenvironment. Hypoxia and inflammation are two critical factors that shape the …
[HTML][HTML] Immune-mediated drug-induced liver injury: immunogenetics and experimental models
A Gerussi, A Natalini, F Antonangeli… - International Journal of …, 2021 - mdpi.com
Drug-induced liver injury (DILI) is a challenging clinical event in medicine, particularly
because of its ability to present with a variety of phenotypes including that of autoimmune …
because of its ability to present with a variety of phenotypes including that of autoimmune …
[HTML][HTML] The importance of patient-specific factors for hepatic drug response and toxicity
VM Lauschke, M Ingelman-Sundberg - International Journal of Molecular …, 2016 - mdpi.com
Responses to drugs and pharmacological treatments differ considerably between
individuals. Importantly, only 50%–75% of patients have been shown to react adequately to …
individuals. Importantly, only 50%–75% of patients have been shown to react adequately to …
Models of idiosyncratic drug-induced liver injury
T Yokoi, S Oda - Annual review of pharmacology and toxicology, 2021 - annualreviews.org
Drug-induced liver injury (DILI) is a leading cause of attrition during the early and late stages
of drug development and after a drug is marketed. DILI is generally classified as either …
of drug development and after a drug is marketed. DILI is generally classified as either …
Invariant natural killer T cells contribute to chronic-plus-binge ethanol-mediated liver injury by promoting hepatic neutrophil infiltration
Neutrophil infiltration is a hallmark of alcoholic steatohepatitis; however, the underlying
mechanisms remain unclear. We previously reported that chronic-plus-binge ethanol …
mechanisms remain unclear. We previously reported that chronic-plus-binge ethanol …
Nanotherapeutics for Alleviating Anesthesia‐Associated Complications
B Lu, L Wei, G Shi, J Du - Advanced Science, 2024 - Wiley Online Library
Current management of anesthesia‐associated complications falls short in terms of both
efficacy and safety. Nanomaterials with versatile properties and unique nano‐bio …
efficacy and safety. Nanomaterials with versatile properties and unique nano‐bio …
Drug bioactivation and protein adduct formation in the pathogenesis of drug-induced toxicity
BK Park, H Laverty, A Srivastava, DJ Antoine… - Chemico-biological …, 2011 - Elsevier
Adverse drug reactions (ADRs) remain a major complication of drug therapy and can be
classified as 'on-target'or 'off-target'(idiosyncratic) reactions. On-target reactions can be …
classified as 'on-target'or 'off-target'(idiosyncratic) reactions. On-target reactions can be …
Involvement of immune-related factors in diclofenac-induced acute liver injury in mice
A Yano, S Higuchi, K Tsuneyama, T Fukami… - Toxicology, 2012 - Elsevier
Drug-induced liver injury (DILI) is a major safety concern in drug development and clinical
drug therapy. However, the underlying mechanism of DILI is little known. It is difficult to …
drug therapy. However, the underlying mechanism of DILI is little known. It is difficult to …