The endoplasmic reticulum (ER) is a dynamic intracellular organelle with multiple functions
essential for cellular homeostasis, development, and stress responsiveness. In response to …

The unfolded protein response (UPR) is a highly conserved protein quality control
mechanism, activated in response to Endoplasmic Reticulum (ER) stress. Signalling is …

During prion disease, an increase in misfolded prion protein (PrP) generated by prion
replication leads to sustained overactivation of the branch of the unfolded protein response …

Several neurodegenerative diseases share common neuropathology, primarily featuring the
presence in the brain of abnormal protein inclusions containing specific misfolded proteins …

Prions cause transmissible neurodegenerative diseases and replicate by conformational
conversion of normal benign forms of prion protein (PrPC) to disease‐causing PrPSc …

Prion diseases and Alzheimer disease (AD) share a variety of clinical and neuropathologic
features (eg progressive dementia, accumulation of abnormally folded proteins in diseased …

The unfolded protein response (UPR) is a conserved adaptive reaction that increases cell
survival under endoplasmic reticulum (ER) stress conditions. X-box-binding protein-1 (XBP …

The aging process is characterized by tissue decline and the onset of age-associated
disease. It is not, however, immutable, and aging can be modulated by various genetic and …

The unfolded protein response (UPR) is a conserved adaptive reaction that increases cell
survival under conditions of endoplasmic reticulum (ER) stress. The UPR controls diverse …

Prion diseases typically have long pre-clinical incubation periods during which time the
infectious prion particle and infectivity steadily propagate in the brain. Abnormal neuritic …