Alzheimer's disease (AD) is the most common cause of dementia and is characterized by
progressive neurodegeneration and cognitive decline. Understanding the pathophysiology …

To match the metabolic demands of the brain, mechanisms have evolved to couple neuronal
activity to vasodilation, thus increasing local cerebral blood flow and delivery of oxygen and …

Structural and functional integrity of the cerebral vasculature ensures proper brain
development and function, as well as healthy aging. The inability of the brain to store energy …

The neurovascular unit (NVU) is a conceptual framework that has been proposed to better
explain the relationships between the neural cells and blood vessels in the human brain …

Abstracts Functional connectivity, which reflects the spatial and temporal organization of
intrinsic activity throughout the brain, is one of the most studied measures in human …

The blood–brain barrier (BBB), built by brain endothelial cells (BECs), is impermeable to
biologics. Liposomes and other nanoparticles are good candidates for the delivery of …

Neurovascular unit mural cells called 'pericytes' maintain the blood-brain barrier and local
cerebral blood flow. Pathological changes in the hippocampus predispose to cognitive …

The response of the blood–brain barrier (BBB) following a stroke, including subarachnoid
hemorrhage (SAH), has been studied extensively. The main components of this reaction are …

Neurovascular coupling (NVC), or the adjustment of blood flow in response to local
increases in neuronal activity is a hallmark of healthy brain function, and the physiological …

Significance: Whether or not capillary pericytes contribute to blood flow regulation in the
brain and retina has long been debated. This was partly caused by failure of detecting the …