The complex machineries involved in replication and transcription translocate along the
same DNA template, often in opposing directions and at different rates. These processes …

Mammalian cells treated with ultraviolet (UV) light provide one of the best-known
experimental systems for depicting the biological consequences of DNA damage. UV …

Cells induce the expression of DNA-repair enzymes, activate cell-cycle checkpoints and,
under some circumstances, undergo apoptosis in response to DNA-damaging agents. The …

Many cancer therapeutics target DNA and exert cytotoxicity through the induction of DNA
damage and inhibition of transcription. We report that a DNA minor groove binding hairpin …

Transcription–replication conflicts occur when the two critical cellular machineries
responsible for gene expression and genome duplication collide with each other on the …

The devastating genetic disorder Cockayne syndrome (CS) arises from mutations in the
CSA and CSB genes. CS is characterized by progressive multisystem degeneration and is …

There have been innumerate demonstrations of p53's activity as a tumour suppressor
protein with the ability to stimulate cell signalling that can lead to cell cycle arrest and cell …

Patients with the genetic disease xeroderma pigmentosum (XP) lack the capacity to carry out
a specific type of DNA repair process called nucleotide excision repair (NER). The NER …

Ultraviolet (UV) radiation is a mutagen of major clinical importance in humans. UV-induced
damage activates multiple signaling pathways, which initiate DNA repair, cell cycle arrest …

The kinetics of DNA repair and RNA synthesis recovery in human cells following UV-
irradiation were assessed using nascent RNA Bru-seq and quantitative long PCR. It was …