Rac1 as a Target to Treat Dysfunctions and Cancer of the Bladder
V Sauzeau, J Beignet, C Bailly - Biomedicines, 2022 - mdpi.com
Bladder pathologies, very common in the aged population, have a considerable negative
impact on quality of life. Novel targets are needed to design drugs and combinations to treat …
impact on quality of life. Novel targets are needed to design drugs and combinations to treat …
Design, synthesis, and molecular modeling studies of a novel benzimidazole as an aromatase inhibitor
In this study, a series of novel 1, 3, 4-oxadiazole-benzimidazole derivatives were designed
and synthesized. Their cytotoxic activities against five cancer cell lines, including A549, MCF …
and synthesized. Their cytotoxic activities against five cancer cell lines, including A549, MCF …
Combined 3D-QSAR and docking analysis for the design and synthesis of chalcones as potent and selective monoamine oxidase B inhibitors
M Mellado, C González, J Mella, LF Aguilar, D Viña… - Bioorganic …, 2021 - Elsevier
Monoamine oxidases (MAOs) are important targets in medicinal chemistry, as their inhibition
may change the levels of different neurotransmitters in the brain, and also the production of …
may change the levels of different neurotransmitters in the brain, and also the production of …
Coumarin-Resveratrol-Inspired Hybrids as Monoamine Oxidase B Inhibitors: 3-Phenylcoumarin versus trans-6-Styrylcoumarin
Monoamine oxidases (MAOs) are attractive targets in drug design. The inhibition of one of
the isoforms (A or B) is responsible for modulating the levels of different neurotransmitters in …
the isoforms (A or B) is responsible for modulating the levels of different neurotransmitters in …
Quantitative structure–activity relationships analysis, homology modeling, docking and molecular dynamics studies of triterpenoid saponins as Kirsten rat sarcoma …
Abstract Oncogenic Kirsten RAt Sarcoma (KRAS) mutations are attractive targets in non-
small-cell lung cancer (NSCLC). Thus, the objective of this work is to discover promising …
small-cell lung cancer (NSCLC). Thus, the objective of this work is to discover promising …
2D-QSAR, 3D-QSAR, molecular docking and ADMET prediction studies of some novel 2-((1H-indol-3-yl) thio)-N-phenyl-acetamide derivatives as anti-influenza A …
Due to the emergence of drug-resistant strains of influenza A virus (IAV) in recent times, the
need to search and discover more potent anti-IAV inhibitors is of great interest, especially …
need to search and discover more potent anti-IAV inhibitors is of great interest, especially …
[PDF][PDF] RETRACTED: In-silico modelling studies of 5-benzyl-4-thiazolinone derivatives as influenza neuraminidase inhibitors via 2D-QSAR, 3D-QSAR, molecular …
Influenza virus disease is one of the most infectious diseases responsible for many human
deaths, and the high mutability of the virus causes drug resistance effects in recent times. As …
deaths, and the high mutability of the virus causes drug resistance effects in recent times. As …
Hyphenated 3D-QSAR statistical model-scaffold hopping analysis for the identification of potentially potent and selective sigma-2 receptor ligands
G Floresta, A Rescifina, A Marrazzo, M Dichiara… - European Journal of …, 2017 - Elsevier
A 3D quantitative structure-activity relationship (3D-QSAR) model for predicting the σ 2
receptor affinity has been constructed with the aim of providing a useful tool for the …
receptor affinity has been constructed with the aim of providing a useful tool for the …
Structure-activity relationships based on 3D-QSAR CoMFA/CoMSIA and design of aryloxypropanol-amine agonists with selectivity for the human β3-adrenergic …
M Lorca, C Morales-Verdejo, D Vásquez-Velásquez… - Molecules, 2018 - mdpi.com
The wide tissue distribution of the adrenergic β3 receptor makes it a potential target for the
treatment of multiple pathologies such as diabetes, obesity, depression, overactive bladder …
treatment of multiple pathologies such as diabetes, obesity, depression, overactive bladder …
Organic compounds based on 1-(prop-2-yn-1-ylamino)-2, 3-dihydro-1H-indene-4-thiol as selective human monoamine oxidase B inhibitors. Quantitative analysis of …
MA El Alaouy, S El Bahi, M Boutalaka… - Moroccan Journal of …, 2023 - revues.imist.ma
Abstract After Alzheimer's disease, Parkinson's disease is the most prevalent
neurodegenerative condition. Because it is fatal and affects a large proportion of the world's …
neurodegenerative condition. Because it is fatal and affects a large proportion of the world's …