The chemokines CXCL8 and CXCL12: molecular and functional properties, role in disease and efforts towards pharmacological intervention
S Cambier, M Gouwy, P Proost - Cellular & Molecular Immunology, 2023 - nature.com
Chemokines are an indispensable component of our immune system through the regulation
of directional migration and activation of leukocytes. CXCL8 is the most potent human …
of directional migration and activation of leukocytes. CXCL8 is the most potent human …
The influence of tumor microenvironment on immune escape of melanoma
A Simiczyjew, E Dratkiewicz, J Mazurkiewicz… - International Journal of …, 2020 - mdpi.com
The low efficiency of currently-used anti-cancer therapies poses a serious challenge,
especially in the case of malignant melanoma, a cancer characterized by elevated …
especially in the case of malignant melanoma, a cancer characterized by elevated …
CellCharter reveals spatial cell niches associated with tissue remodeling and cell plasticity
M Varrone, D Tavernari, A Santamaria-Martínez… - Nature Genetics, 2024 - nature.com
Tissues are organized in cellular niches, the composition and interactions of which can be
investigated using spatial omics technologies. However, systematic analyses of tissue …
investigated using spatial omics technologies. However, systematic analyses of tissue …
Tumor-secreted exosomal miR-141 activates tumor-stroma interactions and controls premetastatic niche formation in ovarian cancer metastasis
Y Mo, LL Leung, CSL Mak, X Wang, WS Chan… - Molecular cancer, 2023 - Springer
Background Metastatic colonization is one of the critical steps in tumor metastasis. A pre-
metastatic niche is required for metastatic colonization and is determined by tumor-stroma …
metastatic niche is required for metastatic colonization and is determined by tumor-stroma …
Wound healing in aged skin exhibits systems-level alterations in cellular composition and cell-cell communication
Delayed and often impaired wound healing in the elderly presents major medical and
socioeconomic challenges. A comprehensive understanding of the cellular/molecular …
socioeconomic challenges. A comprehensive understanding of the cellular/molecular …
Mesenchymal stem cells reduce corneal fibrosis and inflammation via extracellular vesicle-mediated delivery of miRNA
G Shojaati, I Khandaker… - Stem cells …, 2019 - academic.oup.com
Mesenchymal stem cells from corneal stromal stem cells (CSSC) prevent fibrotic scarring
and stimulate regeneration of transparent stromal tissue after corneal wounding in mice …
and stimulate regeneration of transparent stromal tissue after corneal wounding in mice …
Concepts of GPCR‐controlled navigation in the immune system
T Lämmermann, W Kastenmüller - Immunological reviews, 2019 - Wiley Online Library
G‐protein–coupled receptor (GPCR) signaling is essential for the spatiotemporal control of
leukocyte dynamics during immune responses. For efficient navigation through mammalian …
leukocyte dynamics during immune responses. For efficient navigation through mammalian …
Tumour-associated neutrophils secrete AGR2 to promote colorectal cancer metastasis via its receptor CD98hc–xCT
S Tian, Y Chu, J Hu, X Ding, Z Liu, D Fu, Y Yuan… - Gut, 2022 - gut.bmj.com
Objective Reciprocal cellular crosstalk within the tumour microenvironment (TME) actively
participates in tumour progression. The anterior gradient-2 (AGR2) can be secreted to …
participates in tumour progression. The anterior gradient-2 (AGR2) can be secreted to …
Multifunctional integrated nanozymes facilitate spinal cord regeneration by remodeling the extrinsic neural environment
High levels of reactive oxygen species (ROS) and inflammation create a complicated
extrinsic neural environment that dominates the initial post‐injury period after spinal cord …
extrinsic neural environment that dominates the initial post‐injury period after spinal cord …