The mammalian target of rapamycin (mTOR) is a protein kinase that controls cellular
metabolism, catabolism, immune responses, autophagy, survival, proliferation, and …

The reduction in androgen synthesis and the blockade of the androgen receptor (AR)
function by chemical castration and AR signaling inhibitors represent the main treatment …

The analysis of the microvasculature and the assessment of angiogenesis have significant
prognostic value in various diseases, including cancer. The search for invasion into the …

Glioblastoma is a highly aggressive disease with poor patient outcomes despite current
treatment options, which consist of surgery, radiation, and chemotherapy. However, these …

Tumor therapy escape due to undesired side effects induced by treatment, such as
prosurvival autophagy or cellular senescence, is one of the key mechanisms of resistance …

Glioblastoma (GBM) is the most common malignant tumor of the central nervous system
(CNS). It is a leading cause of death among patients with intracranial malignant tumors …

Alternative splicing (AS) serves as a pivotal mechanism in transcriptional regulation,
engendering transcript diversity, and modifications in protein structure and functionality …

Two novel hybrid compounds, CON1 and CON2, have been developed by combining
sclareol (SC) and doxorubicin (DOX) into a single molecular entity. These hybrid …

Nerve/glial antigen (NG) 2 is highly expressed in glioblastoma multiforme (GBM). However,
the underlying mechanisms of its upregulated expression are largely unknown. In silico …

Glioblastoma multiforme (GBM) is the most common, aggressive, and fatal primary
malignant brain tumor in adults. The therapeutic efficacy of temozolomide (TMZ) is limited …