Nephrotoxicity is one of the most important side effects and therapeutical limitations of
aminoglycoside antibiotics, especially gentamicin. Despite rigorous patient monitoring …

Due to high relative blood flow the kidney is prone to drug-induced damage.
Aminoglycoside type antibiotic gentamicin is one of the leading cause of drug-induced …

Aminoglycoside antibiotics are employed clinically because of their potent bactericidal
activities, less bacterial resistance, post-antibiotic effects and low cost. However, drugs …

The complex nature of critical illness often necessitates the use of multiple therapeutic
agents, many of which may individually or in combination have the potential to cause renal …

A potential therapeutic approach to protect or reverse gentamicin-induced oxidative stress
and nephrotoxicity would have more importance for clinical consequences. Therefore, the …

Consistent, sensitive biomarkers of acute kidney injury in animal models and humans have
historically represented a poorly met need for investigators and clinicians. Detection of early …

Acute renal failure (ARF) is a major complication of gentamicin (GM) treatment, which is
effective against gram-negative infections. Since experimental evidence suggests a role of …

The toxicity of gentamicin (GEN) in the kidney seems to relate to the generation of reactive
oxygen species (ROS). Caffeic acid phenethyl ester (CAPE) has been demonstrated to have …

Introduction: Gentamicin sulphate nephrotoxicity seems to be attributed to the generation of
reactive oxygen species. Olive leaf extract (OLE) has been demonstrated to have antioxidant …

The present investigation reports the effect of rosmarinic acid (RA), an antioxidant on
gentamicin sulphate (GS)-induced renal oxidative damage in rats. Rosmarinic acid (RA) has …