Faced with the need to find new anti-inflammatory agents, great effort has been expended
on the development of drugs for the treatment of inflammation. This disorder reduces the …

BACKGROUND: Outcomes from this trial's first year data demonstrated significant benefit in
heart transplant patients treated with pravastatin in cholesterol levels, survival, rejection with …

3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) are widely used
antilipidemic agents that are also immunomodulatory. We evaluated possible effects of …

3-Hydroxy-3-methyl-glutaryl coenzyme A (HMG-CoA) reductase inhibitors, or statins, are
competitive inhibitors of the rate-limiting enzyme in cholesterol synthesis. Several clinical …

Perillyl alcohol (POH) is currently being tested in clinical trials as an anticancer agent,
though its mechanism of action has not been definitively established. We treated two human …

The success of cardiac transplantation is largely attributable to the development of effective
immunosuppressive regimens. The introduction of calcineurin inhibitors was pivotal in …

Cardiac allograft vasculopathy is one of the major causes of mortality late after heart
transplantation. This disease process occurs to a lesser extent in patients with other donor …

Faced with the need to find new anti-inflammatory agents, great effort has been expended
on the development of drugs for the treatment of inflammation. This disorder reduces the …

T-cells and antigen presenting cells are an essential part of the adaptive immune response
system and how they interact is crucial in how the body effectively fights infection or …

Coronary artery disease in the transplanted heart, also known as cardiac allograft
vasculopathy, is one of the major causes of mortality late after heart transplantation. There …