5-Ene-4-thiazolidinones–An efficient tool in medicinal chemistry

D Kaminskyy, A Kryshchyshyn, R Lesyk - European journal of medicinal …, 2017 - Elsevier
The presented review is an attempt to summarize a huge volume of data on 5-ene-4-
thiazolidinones being a widely studied class of small molecules used in modern organic and …

Recent developments with rhodanine as a scaffold for drug discovery

D Kaminskyy, A Kryshchyshyn… - Expert Opinion on Drug …, 2017 - Taylor & Francis
Introduction: Rhodanines, as one of the 4-thiazolidinones subtypes, are recognized as
privileged heterocycles in medicinal chemistry. The main achievements include the …

Synthesis, characterization, and pharmacological evaluation of some novel thiadiazoles and thiazoles incorporating pyrazole moiety as anticancer agents

SM Gomha, TA Salah, AO Abdelhamid - Monatshefte für Chemie …, 2015 - Springer
Abstract Two series of novel 2-[[1-(5-methyl-1-phenyl-5-substituted-1 H-pyrazol-4-yl)
ethylidene] hydrazono]-3-phenyl-2, 3-dihydro-1, 3, 4-thiadiazole derivatives and 2-[5-(4 …

Coumarin: a promising scaffold for anticancer agents

M Kaur, S Kohli, S Sandhu, Y Bansal… - Anti-Cancer Agents in …, 2015 - ingentaconnect.com
Coumarin enjoys an important place in drug discovery process due to its presence in
diversity of biologically active compounds. Many compounds of plant origin are derivatives …

Novel thiadiazole-thiazole hybrids: synthesis, molecular docking, and cytotoxicity evaluation against liver cancer cell lines

GF Aljohani, TZ Abolibda, M Alhilal… - Journal of Taibah …, 2022 - Taylor & Francis
One of the worst diseases, cancer claims millions of lives each year throughout the world,
necessitating the creation of novel treatments. In this study, we designed a novel series of 1 …

Thiazolidinone/thiazole based hybrids–New class of antitrypanosomal agents

A Kryshchyshyn, D Kaminskyy, O Karpenko… - European journal of …, 2019 - Elsevier
Different compounds have been investigated as potent drugs for trypanosomiasis treatment,
but no new drug has been marketed in the past 3 decades. 4-Thiazolidinone/thiazole as …

A review on chemical profile of coumarins and their therapeutic role in the treatment of cancer

K Venkata Sairam, BM Gurupadayya… - Current Drug …, 2016 - ingentaconnect.com
Coumarin class of organic compounds consists of 1, 2-benzopyrone ring system as a basic
parent scaffold. These benzopyrones are subdivided into alpha-benzopyrones and …

Synthesis and Cytotoxicity Evaluation of Some Novel Thiazoles, Thiadiazoles, and Pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-5(1H)-ones Incorporating Triazole …

SM Gomha, SA Ahmed, AO Abdelhamid - Molecules, 2015 - mdpi.com
Reactions of hydrazonoyl halides and each of methyl 2-(1-(5-methyl-1-phenyl-1 H-1, 2, 3-
triazol-4-yl) ethylidene) hydrazine-1-carbodithioate and 2-(1-(5-methyl-1-phenyl-1 H-1, 2, 3 …

5-Ene-4-thiazolidinones induce apoptosis in mammalian leukemia cells

J Senkiv, N Finiuk, D Kaminskyy, D Havrylyuk… - European Journal of …, 2016 - Elsevier
The article presents the synthesis of 5-ene-4-thiazolidinone derivatives with pyrazole core
linked by enamine group. The structure and purity of compounds were confirmed by …

A facile synthesis and anticancer activity of some novel thiazoles carrying 1, 3, 4-thiadiazole moiety

SM Gomha, NA Kheder, MR Abdelaziz… - Chemistry Central …, 2017 - Springer
Abstract Background Thiazoles and 1, 3, 4-thiadiazoles have been reported to possess
various pharmacological activities. Results A novel series of thiazoles carrying 1, 3, 4 …