5-Ene-4-thiazolidinones–An efficient tool in medicinal chemistry
The presented review is an attempt to summarize a huge volume of data on 5-ene-4-
thiazolidinones being a widely studied class of small molecules used in modern organic and …
thiazolidinones being a widely studied class of small molecules used in modern organic and …
Recent developments with rhodanine as a scaffold for drug discovery
D Kaminskyy, A Kryshchyshyn… - Expert Opinion on Drug …, 2017 - Taylor & Francis
Introduction: Rhodanines, as one of the 4-thiazolidinones subtypes, are recognized as
privileged heterocycles in medicinal chemistry. The main achievements include the …
privileged heterocycles in medicinal chemistry. The main achievements include the …
Synthesis, characterization, and pharmacological evaluation of some novel thiadiazoles and thiazoles incorporating pyrazole moiety as anticancer agents
SM Gomha, TA Salah, AO Abdelhamid - Monatshefte für Chemie …, 2015 - Springer
Abstract Two series of novel 2-[[1-(5-methyl-1-phenyl-5-substituted-1 H-pyrazol-4-yl)
ethylidene] hydrazono]-3-phenyl-2, 3-dihydro-1, 3, 4-thiadiazole derivatives and 2-[5-(4 …
ethylidene] hydrazono]-3-phenyl-2, 3-dihydro-1, 3, 4-thiadiazole derivatives and 2-[5-(4 …
Coumarin: a promising scaffold for anticancer agents
M Kaur, S Kohli, S Sandhu, Y Bansal… - Anti-Cancer Agents in …, 2015 - ingentaconnect.com
Coumarin enjoys an important place in drug discovery process due to its presence in
diversity of biologically active compounds. Many compounds of plant origin are derivatives …
diversity of biologically active compounds. Many compounds of plant origin are derivatives …
Novel thiadiazole-thiazole hybrids: synthesis, molecular docking, and cytotoxicity evaluation against liver cancer cell lines
One of the worst diseases, cancer claims millions of lives each year throughout the world,
necessitating the creation of novel treatments. In this study, we designed a novel series of 1 …
necessitating the creation of novel treatments. In this study, we designed a novel series of 1 …
Thiazolidinone/thiazole based hybrids–New class of antitrypanosomal agents
A Kryshchyshyn, D Kaminskyy, O Karpenko… - European journal of …, 2019 - Elsevier
Different compounds have been investigated as potent drugs for trypanosomiasis treatment,
but no new drug has been marketed in the past 3 decades. 4-Thiazolidinone/thiazole as …
but no new drug has been marketed in the past 3 decades. 4-Thiazolidinone/thiazole as …
A review on chemical profile of coumarins and their therapeutic role in the treatment of cancer
K Venkata Sairam, BM Gurupadayya… - Current Drug …, 2016 - ingentaconnect.com
Coumarin class of organic compounds consists of 1, 2-benzopyrone ring system as a basic
parent scaffold. These benzopyrones are subdivided into alpha-benzopyrones and …
parent scaffold. These benzopyrones are subdivided into alpha-benzopyrones and …
Synthesis and Cytotoxicity Evaluation of Some Novel Thiazoles, Thiadiazoles, and Pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-5(1H)-ones Incorporating Triazole …
Reactions of hydrazonoyl halides and each of methyl 2-(1-(5-methyl-1-phenyl-1 H-1, 2, 3-
triazol-4-yl) ethylidene) hydrazine-1-carbodithioate and 2-(1-(5-methyl-1-phenyl-1 H-1, 2, 3 …
triazol-4-yl) ethylidene) hydrazine-1-carbodithioate and 2-(1-(5-methyl-1-phenyl-1 H-1, 2, 3 …
5-Ene-4-thiazolidinones induce apoptosis in mammalian leukemia cells
J Senkiv, N Finiuk, D Kaminskyy, D Havrylyuk… - European Journal of …, 2016 - Elsevier
The article presents the synthesis of 5-ene-4-thiazolidinone derivatives with pyrazole core
linked by enamine group. The structure and purity of compounds were confirmed by …
linked by enamine group. The structure and purity of compounds were confirmed by …
A facile synthesis and anticancer activity of some novel thiazoles carrying 1, 3, 4-thiadiazole moiety
Abstract Background Thiazoles and 1, 3, 4-thiadiazoles have been reported to possess
various pharmacological activities. Results A novel series of thiazoles carrying 1, 3, 4 …
various pharmacological activities. Results A novel series of thiazoles carrying 1, 3, 4 …