Nanopore-based technologies beyond DNA sequencing

YL Ying, ZL Hu, S Zhang, Y Qing, A Fragasso… - Nature …, 2022 - nature.com
Inspired by the biological processes of molecular recognition and transportation across
membranes, nanopore techniques have evolved in recent decades as ultrasensitive …

Engineering biological nanopore approaches toward protein sequencing

X Wei, T Penkauskas, JE Reiner, C Kennard… - ACS …, 2023 - ACS Publications
Biotechnological innovations have vastly improved the capacity to perform large-scale
protein studies, while the methods we have for identifying and quantifying individual proteins …

A guide to signal processing algorithms for nanopore sensors

C Wen, D Dematties, SL Zhang - ACS sensors, 2021 - ACS Publications
Nanopore technology holds great promise for a wide range of applications such as
biomedical sensing, chemical detection, desalination, and energy conversion. For sensing …

Estimation of shape, volume, and dipole moment of individual proteins freely transiting a synthetic nanopore

J Houghtaling, C Ying, OM Eggenberger, A Fennouri… - ACS …, 2019 - ACS Publications
This paper demonstrates that high-bandwidth current recordings in combination with low-
noise silicon nitride nanopores make it possible to determine the molecular volume …

Solid-State Nanopore Distinguishes Ferritin and Apo-Ferritin with Identical Exteriors through Amplified Flexibility at Single-Molecule Level

YD Yin, FF Chen, J Hu, L Yang, XT Song… - Analytical …, 2023 - ACS Publications
Protein identification and discrimination at the single-molecule level are big challenges.
Solid-state nanopores as a sensitive biosensor have been used for protein analysis …

Allosteric Switching of Calmodulin in a Mycobacterium smegmatis porin A (MspA) Nanopore‐Trap

Y Liu, T Pan, K Wang, Y Wang, S Yan… - Angewandte Chemie …, 2021 - Wiley Online Library
Recent developments concerning large protein nanopores suggest a new approach to
structure profiling of native folded proteins. In this work, the large vestibule of Mycobacterium …

[HTML][HTML] Noise in nanopore sensors: Sources, models, reduction, and benchmarking

S Liang, F Xiang, Z Tang, R Nouri, X He… - Nanotechnology and …, 2020 - pubs.aip.org
Label-free nanopore sensors have emerged as a new generation technology of DNA
sequencing and have been widely used for single molecule analysis. Since the first α …

Quantifying nanoparticle layer topography: Theoretical modeling and atomic force microscopy investigations

Z Adamczyk, M Sadowska, M Nattich-Rak - Langmuir, 2023 - ACS Publications
A comprehensive method consisting of theoretical modeling and experimental atomic force
microscopy (AFM) measurements was developed for the quantitative analysis of …

The promise of nanopore technology: Advances in the discrimination of protein sequences and chemical modifications

B Cressiot, L Bacri, J Pelta - Small Methods, 2020 - Wiley Online Library
Only a small percent of human genomic DNA encodes for proteins. Additionally, protein
isoforms variants and chemical modifications are not coded in the genome read by the cell …

High Accuracy Protein Identification: Fusion of Solid‐State Nanopore Sensing and Machine Learning

S Dutt, H Shao, B Karawdeniya… - Small …, 2023 - Wiley Online Library
Proteins are arguably one of the most important class of biomarkers for health diagnostic
purposes. Label‐free solid‐state nanopore sensing is a versatile technique for sensing and …